Sökning: "minimum inhibitory concentration"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden minimum inhibitory concentration.

  1. 1. Using Pharmacokinetic and Pharmacodynamic Principles to Evaluate Individualisation of Antibiotic Dosing – Emphasis on Cefuroxime

    Författare :Anders Viberg; Marie Sandström; Otto Cars; Mats Karlsson; Hartmut Derendorf; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Cefuroxime; pharmacokinetics; pharmacodynamics; dosing individualisation; NONMEM; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

    Sammanfattning : Cefuroxime is a renally eliminated antibiotic used against a variety of different bacterial infections. The pharmacokinetics (PK) for cefuroxime was studied in 97 hospitalized patients using population analysis. To be able to measure cefuroxime in human serum a new sensitive analytical method was developed using mass spectrometry detection. LÄS MER

  3. 2. Pharmacological control of ciliary activity in the young sea urchin larva : cholinergic and monoaminergic effects and the role of calcium and cyclic nucleotides

    Författare :Sherif Soliman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The ciliary activity of the young (prenervous) sea urchin larva, reflected by its swimming intensity, is measured according to a simple method. The changes in ciliary activity from hatching throughout gastrulation commonly show two main peaks coinciding with the two main phases of gastrulation. LÄS MER

  4. 3. In vitro Pharmacodynamics of Antifungal Agents in the Treatment of Candida Infections

    Författare :Anders Lignell; Jan Sjölin; Elisabeth Löwdin; Mats Kalin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amphotericin B; antagonism; Candida; human serum; inhibition; interaction; in vitro; kinetic model; pharmacodynamics; pharmacokinetics; posaconazole; protein binding; voriconazole; Infectious diseases; Infektionssjukdomar; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : Pharmacodynamic studies are important for the optimal use of antimicrobial agents. Combination antifungal therapy may be one method to improve outcome in invasive Candida infections. LÄS MER

  5. 4. Resistance to Fluoroquinolones in Escherichia coli: Prevention, Genetics and Fitness Costs

    Författare :Linda L. Marcusson; Diarmaid Hughes; Karl Drlica; Uppsala universitet; []
    Nyckelord :Biology; Fluoroquinolone; Escherichia coli; Resistance; Gyrase; Topoisomerase IV; MPC; Fitness compensation; Urinary Tract Infection; Biologi;

    Sammanfattning : Antibiotic-resistant bacteria are increasingly a major healthcare problem but very few new classes of antibiotics have been discovered or launched in recent decades. Approaches to dealing with the problem include learning how bacteria evolve to resistance and improving dosing regimens with current antibiotics so as to reduce the selection of resistant bacteria. LÄS MER

  7. 5. Drug-resistance in M. tuberculosis and the characterisation of a new anti-tuberculosis drug-candidate

    Författare :Emma Huitric; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The occurrence of multidrug-resistant (MDR) tuberculosis (TB) has been increasing at alarming levels globally, and the spread of extensively drug-resistant (XDR) M. tuberculosis is threatening the control of tuberculosis. LÄS MER