Sökning: "midbrain development"

Visar resultat 1 - 5 av 63 avhandlingar innehållade orden midbrain development.

  1. 1. Wnts in development : focus on midbrain

    Författare :Emma Rakel Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Studies in the field of embryonic development reveal the temporal and spatial requirement of specific genes/proteins in the formation of a given tissue. The specific knowledge of which genes/proteins regulate development of the ventral midbrain (VM) provides a guideline for the in vitro differentiation of specific cell types therein, such as dopaminergic (DA) neurons. LÄS MER

  3. 2. Mechanisms controlling midbrain dopaminergic neuron development

    Författare :Shanzheng Yang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The degeneration of midbrain dopaminergic (mDA) neurons accounts for some of the main motor symptoms of Parkinson’s disease (PD). Efforts during the last decades have focused on understanding how mDA neurons are generated and maintained with the hope of developing novel stem cell-based replacement therapies. LÄS MER

  4. 3. Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2

    Författare :Elin Andersson; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Medicin människa och djur ; cell replacement; Parkinson?s; dopamine; neuronal specification; development; mesencephalon; TH; neuronal differentiation; proneural genes; transcription factors; bHLH; neurospheres; stem cell; progenitor cell;

    Sammanfattning : Parkinsons disease (PD) is a neurodegenerative disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. LÄS MER

  5. 4. Molecular and cellular characterization of midbrain dopaminergic neuron development

    Författare :Daniel Gyllborg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Midbrain dopaminergic (mDA) development is a complex yet highly controlled mechanistic process that is conserved across species. The understanding of these molecular details can open windows to new avenues of therapeutic medicine. Parkinson’s disease (PD) is a debilitating neurological disorder that to date has no cure or established cause. LÄS MER

  7. 5. Wnt signalling in the development of ventral midbrain dopaminergic neurons

    Författare :Gonçalo de Sá e Sousa de Castelo-Branco; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dopaminergic Neuron; Ventral Midbrain Development; Writs; Dickkopf; beta-catenin; GSK-3beta; Stem Cells; Neural Precursors;

    Sammanfattning : Dopaminergic (DA) neurons in the ventral midbrain (VM) are one of the major cell types lost in Parkinson's disease (PD). Proof-of-principle exists for cell replacement therapies for PD, but wider application is halted by the unavailability of abundant sources of DA neurons. Stem cells might constitute one of these sources. LÄS MER