Sökning: "microprotein"

Hittade 3 avhandlingar innehållade ordet microprotein.

  1. 1. Engineering of the Ultra-stable Cystine Knot Framework of Microproteins : Design, Chemical Synthesis and Structural Studies

    Författare :Teshome Leta Aboye; Ulf Göransson; Julio A. Camarero; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclotides; cystine knot; protein engineering; NMR; solid phase; disulfide rich; ultra-stable; microprotein; PHARMACY; FARMACI; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Ultra-stable cystine knotted microproteins, in which two disulfides and their connecting backbones form a circle that is penetrated by the third disulfide bonds, have attracted high interest due to their resistance to degradation in vitro and potential for the development of peptide drugs. This thesis gives new insights into engineering of that framework of microproteins, including approaches to their chemical synthesis, backbone engineering, structural and biological evaluations. LÄS MER

  3. 2. Structure, Evolution, and Expression of Proteins in the Male Reproductive Tract. Studies on Semenogelins, Beta-Microseminoprotein, and PC3-Secreted Microprotein

    Författare :Camilla Valtonen-André; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PC3-secreted microprotein; Clinical chemistry; Klinisk kemi; Semenogelin; Beta-microseminoprotein;

    Sammanfattning : Human semen has several important constituents, including the prostate secreted proteins beta-microseminoprotein (MSP), prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP), and the seminal-vesicle-derived coagulum proteins semenogelin I (SEMG1) and semenogelin II (SEMG2). The research underlying this thesis explored the evolution, expression and structure of seminal plasma proteins to provide further knowledge in the area of reproduction, particularly regarding MSP and the semenogelins. LÄS MER

  4. 3. Functional screening and molecular characterisation of small proteins

    Författare :Dörte Schlesinger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Proteins are one of the main drivers of cellular function. Most known proteins constitute various hundred amino acids, but growing evidence suggests that additionally thousands of short open reading frames (sORFs) are translated, posing the exciting possibility that many small unknown proteins are yet to be discovered. LÄS MER