Sökning: "microglial cells"

Visar resultat 21 - 25 av 72 avhandlingar innehållade orden microglial cells.

  1. 21. Cell interactions in the CNS and their consequences for neuronal apoptosis

    Författare :Mikaela Berglund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aggregate cultures; apoptosis; automated image analysis; cytochrome c; interactions; JNK; microglia; neuron; neural precursor cells; rotenone; UV.;

    Sammanfattning : The central nervous system consists of an intricate network of neurons and glial cells that depend on reciprocal communication to develop and maintain the vital functions of the brain. if the balance is disturbed by injury or disease, two cell types in particular, microglia and astrocytes, respond by producing factors that help combat the infection or delimit the affected area. LÄS MER

  3. 22. Implications of cholesterol and cholesterol-lowering therapy in Alzheimer's disease

    Författare :Daniel Famer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer s disease; dietary cholesterol; rosuvastatin; apolipoprotein E; alpha-secretase; beta-secretase; alpha- beta-secretase ratio; soluble APPalpha; gliosis; microglial load; interleukin-6; caspase-3; body weight gain; lifestyle-preventive strategy; 24 S -hydroxycholesterol; 27-hydroxycholesterol;

    Sammanfattning : BACKGROUND: Alzheimer's disease (AD) is a severe neurodegenerative disease that mainly afflicts elderly persons, with a characteristic progressive decline of cognitive functions and dementia. It is believed that the majority of all AD patients are affected by the sporadic form, thus caused by the combined effects of several risk factors, such as elevated cholesterol levels in midlife and deficiencies in the lipoprotein transporters apolipoprotein E (ApoE). LÄS MER

  4. 23. Immune regulation within the central nervous system and its role in demyelinating diseases

    Författare :Bao-Guo Xiao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) and its animal model, experimental allergic encephalomyelitis (EAE), are diseases of the central nervous system (CNS) characterized by perivascular mononuclear inflammation and oligodendrocyte loss with demyelination. However, it is still not clear whether the pathology in MS and EAE is due to neuroantigen-specific CD4+ T cell-mediated autoimmune responses and/or bystander myelin damage resulting from an inflammatory response. LÄS MER

  5. 24. Repopulation of a microglia-depleted central nervous system : molecular characterization during homeostasis and disease

    Författare :Jinming Han; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Microglia are predominant tissue resident macrophages within the central nervous system (CNS), and contribute to both CNS development and homeostasis. During disease conditions microglia undergo transcriptional re-programming and their dysfunction is implicated in a multitude of disorders, such as multiple sclerosis (MS). LÄS MER

  7. 25. Photoreceptor degeneration, second order neuron remodeling and glia reactivity in an in vivo and in vitro model of retinal neurodegeneration

    Författare :Tanzina Mollick; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicin; Biomedicine;

    Sammanfattning : Photoreceptors have the ability to last during the entire lifespan of an individual. Being the first line of neurons in the visual transduction pathway, their health and maintenance is eminent for proper retinal function. However, photoreceptors are susceptible to neurodegenerative retinal dystrophies. LÄS MER