Sökning: "microfluorometry"

Hittade 5 avhandlingar innehållade ordet microfluorometry.

  1. 1. The interplay of ions in the stimulation of the pancreatic -cell

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Michael Eberhardson; Uppsala universitet.; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; diabetes; pancreatic β-cells; cytoplasmic calcium; oscillations; glucose; tetrodotoxin; tolbutamide; veratridine; tetraethylammonium; quinine; cesium; H2DIDS; furosemide; transients; microfluorometry; fura-2; MQAE; calcium channels; potassium channels; sodium channels; chloride channels; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Glucose stimulation of insulin release is mediated by depolarisation of the pancreatic β-cells with accompanying entry of Ca2+ through voltage-dependent channels. An important feature of the glucose-induced depolarisation is its rhythmicity causing oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), which trigger pulsatile release of insulin. LÄS MER

  2. 2. Pulsatile insulin release from single islets of Langerhans

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Johanna Westerlund; Uppsala universitet.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; islets of Langerhans; insulin; ELISA; cytoplasmic calcium; oscillations; type 2 diabetes; glucose; diazoxide; potassium; tolbutamide; DNP; antimycin A; iodoacetamide; microfluorometry; fura-2; KATP channels; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Insulin release from single islets of Langerhans is pulsatile. The secretory activities of the islets in the pancreas are coordinated resulting in plasma insulin oscillations. Nutrients amplitude-regulate the insulin pulses without influencing their frequency. LÄS MER

  3. 3. Regulation of organelle Ca²+ in individual pancreatic β-cells

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anders Tengholm; Uppsala universitet.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; pancreatic b-cell; inracellular Ca2 stores; furaptra; endoplasmic reticulum; digitonin; a toxin; glucose; ATP; thapsigargin; inositol 1; 4; 5-trisphosphate; ryanodine receptors; cyclic ADP ribose; nicotinic acid adenine dinucleotide phosphate; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : The Ca2+ion plays a fundamental role in the control of a variety of cellular functions, including insulinsecretion from pancreatic β-cells. Whereas the concentration of free Ca2+ in the cytoplasm ([Ca2+]i) ismaintained at low levels (5O-100 nM), some organelles contain high concentrations of the ion. LÄS MER

  4. 4. Age pigments and the biochemical basis of their formation

    Detta är en avhandling från Linköping : Linköpings universitet

    Författare :Dazhong Yin; Linköpings universitet.; Linköpings universitet.; [1995]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Sammanfattning : The autofluorescent, yellow-brown pigments that accumulate over time inbiological organisms are called age pigments. Lipofuscin, known as a hallmark of aging, refers to intracellular age pigments that accumulate mainly in the lysosomes of postrnitotic cells. LÄS MER

  5. 5. Molecular mechanisms involved in the generation of calcium signals In insulin secreting cells

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Clinical Science and Education, Södersjukhuset

    Författare :Kalaiselvan Krishnan; Karolinska Institutet.; Karolinska Institutet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Intracellular Ca 2+ regulates diverse cellular functions in almost all the cells. In the pancreatic ß-cells, Ca 2+ signals are critical for insulin secretion. An increase in the cytoplasmic free Ca 2+ concentration ([Ca 2+ ]i) triggers insulin secretion. LÄS MER