Sökning: "microdialysate"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet microdialysate.

1. 1. Liquid Chromatography-Mass Spectrometry as a Tool for Drug Metabolite Identification in Biological Fluids : With Application to Ketobemidone

   Författare :Ingela Sundström; Per Andrén; Douglas Westerlund; Monika Johansson; Uppsala universitet; []
   Nyckelord :Analytical chemistry; LC-MS MS; accurate mass measurement; drug metabolites; microdialysate; brain; fluorinated stationary phase; phenylboronic acid; retention mechanism; Analytisk kemi;

   Sammanfattning : Electrospray ionization (ESI) mass spectrometry (MS) in combination with liquid chromatography (LC) is an excellent tool for the identification of drug metabolites. Utilizing this hyphenated technique in combination with proper sample pretreatment, the metabolic pathways of the analgesic drug ketobemidone were investigated in human urine and rat microdialysate from blood and brain. LÄS MER

3. 2. Applying proteomics and metabolomics for studying human skeletal muscle with a focus on chronic trapezius myalgia

   Författare :Jenny Hadrévi; Albert Crenshaw; Fatima Pedrosa-Domellöf; Fredrik Hellström; Bijar Ghafouri; Mary F Barbe; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Trapezius myalgia; proteomics; 2D-DIGE; metabolomics; microdialysate; biopsies; anatomi; Human Anatomy;

   Sammanfattning : Work related musculoskeletal disorders are the dominating causes of reported ill-health in industrialized countries. These chronic pain conditions are one of the most costly public health problems in Europe and North America. LÄS MER

4. 3. Physiological and pathophysiological regulation of ECL-cell activity

   Författare :Maria Lundgren; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacy; toxicology; Pharmacological sciences; pharmacognosy; Gastroenterologi; endothelin; gastrin; ischemia-reperfusion; Physiology; Fysiologi; Gastro-enterology; pancreastatin; histamine; microdialysis; ECL-cell; stomach; Farmakologi; farmakognosi; farmaci; toxikologi;

   Sammanfattning : The ECL cells are endocrine/paracrine cells located in the acid-producing part of the stomach. They produce and secrete histamine and chromogranin A-derived peptides in response to circulating gastrin. Mobilized histamine stimulates acid secretion from adjascent parietal cells. LÄS MER

5. 4. Monitoring of antiepileptic drugs using microdialysis : methodological and clinical aspects

   Författare :Martin Lindberger; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : In therapeutic monitoring of antiepileptic drugs (AEDs) the level of unbound drug at the sampling site should ideally equal the unbound concentration at receptor sites. Microdialysis enables direct sampling of the unbound drug concentration and avoids some of the difficulties encountered with ex vivo protein binding. LÄS MER

7. 5. Intravasal microdialysis as a novel technique to monitor metabolism in myocardial ischemia and critical illness

   Författare :Tobias Bäckström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cardiac surgery; glycerol; gut ischemia; hemorrhagic shock; intravasal; L Pratio; microdialysis; myocardial infarction; myocardial ischemia; reperfusion; sepsis;

   Sammanfattning : Rapid detection of post-operative myocardial ischemia is of great value in the treatment of patients undergoing cardiac surgery. With the methods readily available in modem thoracic intensive care units post-operative myocardial ischemia is difficult to detect, and the risk of myocardial ischemia and other complications after cardiac surgery is particularly high in patients with concurrent co-morbidity. LÄS MER