Sökning: "microarray expression analysis"

Visar resultat 1 - 5 av 303 avhandlingar innehållade orden microarray expression analysis.

1. 1. Weighted Analysis of Microarray Experiments

   Författare :Anders Sjögren; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA microarray; differential expression; gene expression; quality control QC ; quality assurance QA ; quality assessment; generalised linear model; empirical Bayes; weighted moderated statistic; invalid p-value; heteroscedasticity; WAME; heteroscedasticity;

   Sammanfattning : DNA microarrays are strikingly efficient tools for analysing gene expression for large sets of genes simultaneously. The aim is often to identify genes which are differentially expressed between some studied conditions, thereby gaining insight into which cellular mechanisms are differently active between the conditions. LÄS MER

3. 2. Microarray Based Gene Expression Analysis in Cancer Research

   Författare :Cecilia Laurell; Joakim Lundberg; Peter Nilsson; Karin Dahlman-Wright; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adrenocortical tumour; apoptosis; cancer; classification; gene expression; microarray; p53; RNA amplification; Molecular biology; Molekylärbiologi;

   Sammanfattning : Biotechnological inventions during the 20th century have resulted in a wide range of approaches for explorations in the functional genomics field. Microarray technology is one of the recent advances which have provided us with snapshots of which genes are expressed in cells of various tissues and diseases. LÄS MER

4. 3. Genomic profiling of breast cancer by microarray-based technology and bioinformatics

   Författare :Johan Staaf; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Survival; Prognostic predictor; Gene Expression; ERBB2; HER2; Microarray; Copy Number Analysis; CGH; aCGH; Amplification; Gene expression analysis;

   Sammanfattning : Cancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to treatment. LÄS MER

5. 4. Approaches to differential gene expression analysis in atherosclerosis

   Författare :Tove Andersson; KTH; []
   Nyckelord :representational difference analysis; gene expression profiling; microarray analysis; atherosclerosis; foam cell formation;

   Sammanfattning : Today’s rapid development of powerful tools for geneexpression analysis provides unprecedented resources forelucidating complex molecular events.The objective of this workhas been to apply, combine andevaluate tools for analysis of differential gene expressionusing atherosclerosis as a model system. LÄS MER

7. 5. Probalistic Methods In Genomic Data Analysis

   Författare :Thomas Breslin; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pathway profiling; Bioinformatics; medical informatics; biomathematics biometrics; Bioinformatik; medicinsk informatik; differential gene expression; probabilistic methods; Natural science; Naturvetenskap; biomatematik; annotation analysis; microarray; Fysicumarkivet A:2004:Breslin;

   Sammanfattning : In this thesis, three aspects of gene expression data analysis are discussed: Differential gene expression is addressed by a probabilistic method. Gene annotation enrichment analysis is discussed in the context of multiple hypothesis testing and the choice of null hypothesis. LÄS MER