Sökning: "microRNA"

Visar resultat 11 - 15 av 118 avhandlingar innehållade ordet microRNA.

  1. 11. Exosomal Shuttle RNA

    Författare :Karin Ekström; Göteborgs universitet; []
    Nyckelord :exosomes; exosomal; shuttle; RNA; esRNA; vesicles; mast cell; gene transfer; microRNA;

    Sammanfattning : Exosomes are small membrane nanovesicles of endocytic origin that can be released by many different cells to the extracellular environment. Exosomes have been found in a number of body fluids such as blood plasma, breast milk, bronchoalveolar lavage fluid and urine, indicating relevance in vivo. LÄS MER

  3. 12. Deregulation and editing of microRNAs in metastatic prostate cancer

    Författare :Gjendine Voss; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; bone metastasis; microRNA; RNA editing; A-to-I editing; ADAR; miR-96; miR-379;

    Sammanfattning : Prostate cancer bone metastasis is still not fully understood, and increased knowledge could aid in the development of better treatment options for patients in the future. This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. LÄS MER

  4. 13. Prognostic Markers in Diffuse Large B-cell Lymphoma : How Bad can it be

    Författare :Gustaf Hedström; Gunilla Enblad; Francesco D'Amore; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DLBCL; Survival; Mast cell; Microenvironment; MicroRNA; MDM2; Polymorphism; Age; Epidemiology; Oncology; Onkologi;

    Sammanfattning : Diffuse large B-cell lymphoma (DLBCL), which is the most common type of lymphoma, is characterised by its aggressiveness and poor outcome without adequate treatment and also for its biological and clinical heterogeneity. It is therefore highly desirable to gain a more profound understanding of the underlying biology of the disease, as well as predictive factors for the guidance of treatment. LÄS MER

  5. 14. Genetic Analyses of Tumor Progression in Colorectal Cancer

    Författare :Kristina Lagerstedt; Göteborgs universitet; []
    Nyckelord :colorectal cancer; tumor progression; microarray; DNA aberration; gene expression; microRNA; structural variation;

    Sammanfattning : Colorectal tumors are responsible for more than 600 000 deaths per year worldwide and thereby constitute the second most common cause of cancer related mortality. Early detection is related to improved prognosis and identification of genetic biomarkers would meliorate available diagnostic tools. LÄS MER

  7. 15. Non-coding RNAs and Extracellular Vesicles in Cutaneous Squamous Cell Carcinoma

    Författare :Chen Li; Andor Pivarcsi; Gareth Inman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cutaneous squamous cell carcinoma; microRNA; long non-coding RNA; extracellular vesicle;

    Sammanfattning : Cutaneous squamous cell carcinoma (cSCC) ranks among the most widespread malignancies with metastatic potential. Investigating the molecular mechanism of tumorigenesis will enhance our understanding of cSCC. Aberrant expression of non-coding RNAs has been extensively reported in human cancers. LÄS MER