Sökning: "microRNA biogenesis"

Hittade 5 avhandlingar innehållade orden microRNA biogenesis.

  1. 1. microRNAs: from biogenesis to organismal tracing

    Författare :Wenjing Kang; Marc Friedländer; Jens Lagergren; Ulf Ørom; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microRNA; microRNA biogenesis; taxonomical identification; high throughput sequencing; xenomiRs; RNA structure; high throughput screening; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : MicroRNAs (miRNAs) are short noncoding RNAs of around 22 nucleotides in length, which help to shape the expression of most mRNAs. Perturbation of miRNA expression has revealed a variety of defects in development, cell specification, physiology and behavior. LÄS MER

  3. 2. A small amoeba at the crossroads of the big RNAi world : MicroRNA biogenesis and Argonaute function in Dictyostelium discoideum

    Författare :Zhen Liao; Fredrik Söderbom; Gerhart E. H. Wagner; Christina Dixelius; Kriton Kalantidis; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNAi; microRNA; Argonaute protein; miRNA biogenesis; Dictyostelium discoideum; social amoeba; Dicer; development; growth; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Small non-coding RNA (ncRNA) mediated gene silencing, known as RNAi, is a key regulatory mechanism of gene expression in eukaryotes. MicroRNAs (miRNA), one major type of small ncRNAs, are about 21nt long and bound by Argonaute proteins. LÄS MER

  4. 3. Visualization and manipulation of microRNA in neural cells

    Författare :Rohit Sachdeva; Molekylär neurogenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microRNA; miRNA; miR-124; miR-9; embryonic stem cells; neural stem cell; cell transplantation; neurogenesis; microglia;

    Sammanfattning : microRNA (miRNA) are small non-coding RNA, 21-23 nucleotides long. miRNA provide a new layer of regulatory control over gene expression programs. It is increasingly evident that miRNA are cell type and tissue specific. Many miRNAs have been identified to be highly abundant in certain regions of the brain. LÄS MER

  5. 4. Diversifying the transcriptome : Adenosine-to-inosine RNA editing in the mammalian brain

    Författare :Albin Widmark; Neus Visa; Joshua Rosenthal; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA editing; ADAR; microRNA; brain development; neuron; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Metazoan transcriptomes are extensively modified by adenosine-to-inosine (A-to-I) RNA editing, a process by which adenosines within double-stranded RNA are enzymatically deaminated to form inosines. Inosines has base-pairing characteristics similar to guanosine, meaning that A-to-I RNA editing results in functional rewriting of transcripts, affecting many biological processes. LÄS MER

  7. 5. Towards Better Understanding of Etiological Mechanisms at the Neuromuscular Junction

    Författare :Evgenii Bogatikov; Anna Rostedt Punga; Klas Kullander; Viktorija Kenina; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuromuscular junction; Muscle cells; Microelectrode array; MicroRNA; Clinical Neurophysiology; Klinisk neurofysiologi; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap;

    Sammanfattning : The neuromuscular junction (NMJ) serves as a model for understanding the mechanisms that determine communication between neurons and their target cells. Disorders of the NMJ can be either autoimmune or genetic (hereditary). LÄS MER