Sökning: "mice"

Visar resultat 11 - 15 av 2577 avhandlingar innehållade ordet mice.

1. 11. Of Mice and MYC : Modelling Medulloblastoma

   Författare :Oliver Mainwaring; Fredrik J. Swartling; Charles Eberhart; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medulloblastoma; MYC; Group 3; Cdkn2a; ARF; HSP90; Chromosome 17q; Medicinsk vetenskap; Medical Science; Oncology; Onkologi;

   Sammanfattning : Brain tumours are the leading cause of cancer-related paediatric deaths, with medulloblastoma (MB) being the most common malignant paediatric brain tumour. MB is stratified into four major subgroups – WNT, SHH, Group 3, and Group 4, nomenclature defined by key pathways and drivers involved within each subgroup. LÄS MER

3. 12. Immunological aspects of maternal-foetal interactions in mice

   Författare :Marie Arvola; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Neonatal mice; milk; placenta; fetal rejection; IgG; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Developmental Biology; miljömedicinsk utvecklingsbiologi;

   Sammanfattning : Mammalian pregnancy is an immunological paradox. The foetus, which expresses both paternal and maternal cell-surface molecules, has to be protected from rejection by the maternal immune system. At the same time, the mother has to have an efficient immune defence and must provide her offspring with antibodies. LÄS MER

4. 13. Cardiovascular effects of growth hormone. Studies in genetically engineered mice

   Författare :Irene Andersson; Göteborgs universitet; []
   Nyckelord :acromegaly; autonomic nervous system; cardiovascular disease; cardiac function; vascular function; growth hormone; heart rate variability; hypertension; insulin-like growth factor-1; transgenic mice;

   Sammanfattning : The general aim of this thesis was to enhance the understanding on the relationships between growth hormone (GH) and cardiovascular disease using genetically engineered mice. More specifically the effects of GH on blood pressure (BP), vascular and cardiac function, atherosclerosis and autonomic control of heart rate were studied. LÄS MER

5. 14. Blood Flow Regulation and Inflammatory Response in Experimental Models of Diabetes

   Författare :Ulrika Pettersson; Mia Phillipson; Leif Jansson; Johanna Henriksnäs; Mikael Rydén; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Islets; beta-cells; pancreas; inflammation; obesity; adipose tissue; rats; mice; leukocytes; beta3-adrenoceptors; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Type 2 diabetes is caused by defect pancreatic islet β-cells together with peripheral insulin resistance. The disease is often accompanied by obesity with associated low-grade visceral adipose tissue inflammation, which contributes to insulin resistance. LÄS MER

7. 15. Effects of growth hormone on bone tissue in transgenic mice

   Författare :Jonas Sandstedt; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; bone; ovariectomy; orchidectomy; growth; Interleukin-6; titanium; transgenic mice;

   Sammanfattning : Growth hormone (GH) affect bone-tissue in both humans and rodents. Also sex steroids are important for growth and the maintenance of normal bone physiology. The specific aims of this study were to investigate how high levels of GH affects bone tissue in mice and to determine whether these effects are dependent on an intact gonadal function. LÄS MER