Sökning: "miRNA biogenesis"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden miRNA biogenesis.

1. 1. A small amoeba at the crossroads of the big RNAi world : MicroRNA biogenesis and Argonaute function in Dictyostelium discoideum

   Författare :Zhen Liao; Fredrik Söderbom; Gerhart E. H. Wagner; Christina Dixelius; Kriton Kalantidis; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNAi; microRNA; Argonaute protein; miRNA biogenesis; Dictyostelium discoideum; social amoeba; Dicer; development; growth; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Sammanfattning : Small non-coding RNA (ncRNA) mediated gene silencing, known as RNAi, is a key regulatory mechanism of gene expression in eukaryotes. MicroRNAs (miRNA), one major type of small ncRNAs, are about 21nt long and bound by Argonaute proteins. LÄS MER

3. 2. microRNAs: from biogenesis to organismal tracing

   Författare :Wenjing Kang; Marc Friedländer; Jens Lagergren; Ulf Ørom; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microRNA; microRNA biogenesis; taxonomical identification; high throughput sequencing; xenomiRs; RNA structure; high throughput screening; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : MicroRNAs (miRNAs) are short noncoding RNAs of around 22 nucleotides in length, which help to shape the expression of most mRNAs. Perturbation of miRNA expression has revealed a variety of defects in development, cell specification, physiology and behavior. LÄS MER

4. 3. Visualization and manipulation of microRNA in neural cells

   Författare :Rohit Sachdeva; Molekylär neurogenetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microRNA; miRNA; miR-124; miR-9; embryonic stem cells; neural stem cell; cell transplantation; neurogenesis; microglia;

   Sammanfattning : microRNA (miRNA) are small non-coding RNA, 21-23 nucleotides long. miRNA provide a new layer of regulatory control over gene expression programs. It is increasingly evident that miRNA are cell type and tissue specific. Many miRNAs have been identified to be highly abundant in certain regions of the brain. LÄS MER

5. 4. All Roads Lead to the Non-Coding RNome : Evolution of Multicellularity and Host Response to Bacterial Infection

   Författare :Jonas Kjellin; Fredrik Söderbom; Jonathan Chubb; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ncRNA; Dictyostelia; miRNA; Class I RNA; host-pathogen interaction; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Sammanfattning : The ability to control gene expression is fundamental for all living organisms. Therefore, a large variety of regulatory mechanisms exist in each cell which are essential for e.g. developmental processes and to quickly adapt to different cellular stresses such as infection. LÄS MER

7. 5. The deep evolutionary roots of non-coding RNA - a comparative genomics approach

   Författare :Marc Patrick Hoeppner; Anthony M. Poole; Britt-Marie Sjöberg; Jürgen Brosius; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; non-coding RNA; evolution; comparative genomics; RNA world; introns; snoRNA; miRNA; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

   Sammanfattning : Non-coding RNAs (ncRNA) are a diverse group of genes that do not encode proteins but function exclusively on the level of RNA and were originally suggested to be remnants of a pre-DNA stage of life known as the RNA world. More recent work, however, has uncovered a rich repertoire of previously unknown families with possible consequences for our understanding of the origin and evolution of the modern RNA infrastructure. LÄS MER