Sökning: "mgla"

Hittade 4 avhandlingar innehållade ordet mgla.

  1. 1. Mechanisms of the intracellular survival of Francisella tularensis

    Författare :Linda Tancred; Anders Sjöstedt; Jean Celli; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; Igl; MglA; J774; IFN-γ; RNS; ROS; phagosome; Clinical bacteriology; Klinisk bakteriologi; mikrobiologi; Microbiology;

    Sammanfattning : Francisella tularensis is a gram-negative, highly virulent, intracellular bacterium which causes the zoonotic disease tularemia. The subspecies tularensis and holarctica are clinically important, and the former is the more virulent. The intracellular lifestyle of F. LÄS MER

  3. 2. The oxidative stress response of Francisella tularensis

    Författare :Marie Honn; Anders Sjöstedt; Helena Lindgren; Andres Melendez; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; FupA; MglA; OxyR; ROS; oxidative stress; molekylärbiologi; Molecular Biology;

    Sammanfattning : Francisella tularensis is capable of infecting numerous cell types, including professional phagocytes. Upon phagocytosis, F. tularensis resides within the phagosome before escaping into the cytosol to replicate. Phagocytes constitute a hostile environment rich in ROS, which are employed as a means of killing pathogens. LÄS MER

  4. 3. Effects of Francisella tularensis infection on macrophage intracellular signaling

    Författare :Maxim Telepnev; Agneta Richter-Dalfors; Umeå universitet; []
    Nyckelord :Clinical Bacteriology; klinisk bakteriologi;

    Sammanfattning : Microbes contain a number of structural components, also known as pathogen associated molecular patterns (PAMP), which can be recognized by the host defense system. The PAMP serve as ligands for Toll-like receptors (TLR) expressed on phagocytic cells. LÄS MER

  5. 4. Francisella tularensis infection induces macrophage cell death

    Författare :Xin-He Lai; Erik Kihlström; Umeå universitet; []
    Nyckelord :klinisk bakteriologi; Clinical Bacteriology;

    Sammanfattning : Francisella tularensis, the causative agent of tularemia, is a potent human and animal pathogen. Its principal survival mechanism is rapid intracellular multiplication. LÄS MER