Sökning: "methylated metabolites"

Hittade 5 avhandlingar innehållade orden methylated metabolites.

  1. 1. Clinical studies of thiopurine metabolism in inflammatory bowel disease

    Författare :Ulf Hindorf; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastroenterologi; Gastro-enterology; thiopurine methyltransferase; 6-mercaptopurine; azathioprine; Inflammatory bowel disease; thiopurines; adverse events; methylated metabolites; thioguanine nucleotides;

    Sammanfattning : Inflammatory bowel disease (IBD, i.e. primarily Crohn's disease and ulcerative colitis) is characterised by a chronic or relapsing inflammation of the digestive tract. LÄS MER

  3. 2. Exposure to inorganic arsenic in pregnancy and metabolism-nutrition interaction

    Författare :Li Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inorganic arsenic is metabolized by most mammals, including humans, via alternating reduction and oxidative methylation with S-adenosylmethionine as main methyl donor. Thus, it seems likely that it is influenced by the availability of methyl groups. LÄS MER

  4. 3. Bioanalytical development for application in therapeutic drug monitoring : focus on drugs used in psychiatry

    Författare :Daniel Öhman; Olof Beck; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Introduction: Since the 1950s and onwards, many new psychoactive drugs have been successfully introduced in clinical practice. A common feature of these drugs is a profound metabolism before clearance from the body. LÄS MER

  5. 4. Interindividual differences in thiopurine metabolism : studies with focus on inflammatory bowel disease

    Författare :Sofie Haglund; Sven Almer; Jan Söderman; Curt Peterson; Åke Nilsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The thiopurines, 6-mercaptopurine and its prodrug azathioprine, are used in the treatment of inflammatory bowel disease, ulcerative colitis and Crohn´s disease. The main active metabolites are the phosphorylated thioguanine nucleotides (6-TGNs) and methylated thioinosine monophosphate (meTIMP). LÄS MER

  7. 5. Developmental immunotoxicity of early-life arsenic exposure

    Författare :Sultan Ahmed; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Arsenic exposure, mainly via drinking water and certain food, is a major public health concern because of its association with various types of cancers and other non-cancer adverse health effects. Worldwide, more than one hundred million people are exposed to elevated levels of arsenic on a regular basis. LÄS MER