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Visar resultat 1 - 5 av 57 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Methotrexate and Risk of Cutaneous Melanoma

   Författare :Sam Polesie; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; methotrexate; cutaneous melanoma; risk; organ transplant recipients; dermoscopy;

   Sammanfattning : Methotrexate (MTX) is an anti-inflammatory and immunosuppressive drug commonly used to treat psoriasis, psoriatic arthritis and rheumatoid arthritis. Cutaneous malignant melanoma (CMM) is a common and dangerous type of skin cancer and in recent decades a noteworthy increase in incidence has been observed. LÄS MER

3. 2. Different aspects of psoriasis etiology and treatment

   Författare :Ingela Flytström; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psoriasis; Staphylococcus aureus; Candida; Methotrexate; Ciclosporin; Dermatology Life Quality Index; Psoriasis Area and Severity Indes; Visual Analoogue Scale; Obesity; Dental Caries; Periodontal disease;

   Sammanfattning : Psoriasis is a chronic disease where treatments are often needed throughout life. The quality of life of patients is often affected and comorbidities are common. LÄS MER

4. 3. Intestinal Mucosa Reconstitution and Protection: Impact of Luminal Factors

   Författare :Yilei Mao; Lund Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Probiotics; Pectin; Oat; Methotrexate; Lactobacilli; Intestinal injury; Intestinal immunity; Intestinal barrier; Enterocolitis; Fiber; Radiation; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

   Sammanfattning : The gastrointestinal mucosa is one of the most rapidly proliferating tissues in the body, and serves as a barrier to luminal bacteria and toxins. Enteral nutrition, luminal fiber and probiotics are of crucial importance for the integrity of this barrier. LÄS MER

5. 4. Drug Delivery to the Brain by Liposomes : Understanding Factors Governing Delivery Outcomes In Vivo

   Författare :Yang Hu; Margareta Hammarlund-Udenaes; Teresa Dalla Costa; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nanocarrier; liposome; blood-brain barrier; brain delivery; formulation; methotrexate; diphenhydramine; microdialysis; pharmacokinetics; model-based approach; Farmaceutisk vetenskap; Pharmaceutical Science; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

   Sammanfattning : The blood-brain barrier (BBB) is the primary obstacle for efficient drug delivery to the central nervous system (CNS). One promising strategy to enhance brain delivery is to utilize nanocarriers (NC), e.g., liposomes, encapsulating CNS drugs. LÄS MER

7. 5. Studies of cerebral blood flow and cerebrospinal fluid in childhood acute lymphoblastic leukemia

   Författare :Gustaf Österlundh; Göteborgs universitet; []
   Nyckelord :childhood acute lymphoblastic leukemia; methotrexate; neurotoxicity; cerebral blood flow; single photon emission computed tomography; cerebrospinal fluid; neuron-specific enolase; glia fibrillary acidic protein; neurofilament; ascorbyl radical;

   Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and more than 80% of the patients are cured today. Treatment might cause side effects and central nervous system (CNS) irradiation has been replaced by systemic high-dose methotrexate (MTX) and intrathecal (IT) MTX due to the risk of late effects. LÄS MER