Avancerad sökning

Hittade 4 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. The non-human primate as a model of human parkinsonism

    Författare :Alison McCormack; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Parkinson s disease; substantia nigra; aging; neuromelanin; MPTP; alpha-synuclein; levodopa; dyskinesia; methamphetamine;

    Sammanfattning : The motor deficits seen in Parkinson’s disease (PD) are the result of a loss of catecholaminergic neurons from the substantia nigra (SN) and the associated loss of striatal dopamine. Clinical signs become evident once striatal dopamine levels decline by at least 70-80% and nigral cell numbers by 40%, and worsen with increased duration of the disease. LÄS MER

  3. 2. Analytical and Toxicological Aspects of Drug Incorporation into Human Hair

    Författare :Robert Kronstrand; Pascal Kintz; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The overall purpose of this thesis was to develop analytical methods for the determination of drugs and melanin content of human hair for practical use in forensic and clinical toxicology. The thesis consists of five papers, two of which are controlled single dose studies where codeine or selegiline were administered to healthy volunteers. LÄS MER

  4. 3. Sex, drugs and intersecting risks : HIV among people who belong to more than one key population in the United States

    Författare :Lina Nerlander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: The HIV epidemic in the United States (US) is mainly concentrated in so-called ‘key populations’ including men who have sex with men (MSM) and people who inject drugs (PWID). In addition, other groups such as people of low socioeconomic status and people belonging to some ethnic minorities have a higher prevalence of HIV. LÄS MER

  5. 4. Biochemical and pharmacological studies of transmethylation mechanisms in the central nervous system

    Författare :Mohammed Saleh Yassin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; clioquinol; dementia; L-methionine S-adenosyltransferase; Parkinson s disease; S-adenosylhomocysteine; S-adenosylmethionine; schizophrenia; subacute myelo-optic neuropathy SMON ; vitamin B12 cyanocobalamin andneuroleptics; Neurovetenskap; Neurology; Neurologi; medicinsk farmakologi; Medical Pharmacology;

    Sammanfattning : Transmethylation is a biochemical process that involves the transfer of a methyl group from a donor to an acceptor compound. Transmethylation reactions are involved in the biosynthesis of nucleic acids, proteins,phospholipids and catecholamines and are therefore essential for the survival of all living organisms. LÄS MER