Sökning: "methadone"
Visar resultat 11 - 15 av 21 avhandlingar innehållade ordet methadone.
11. Drug use, mortality and outcomes among drug users in the general population and in methadone maintenance treatment
Sammanfattning : The two general aims of this thesis were to longitudinally analyse the association between drug use experience among young men and mortality and socio-economic situation up to late middle age and secondly the impact of methadone maintenance treatment on opiate dependents life course. Study I and II were based on a cohort of 48 024 of 50 465 men, born in 1949-51 and compulsory conscripted in 1969/70. LÄS MER
12. Drug-related deaths in Stockholm during the period 1985-1994 : causes and manners of death in relation to type of drug abuse, HIV-infection and methadone treatment
Sammanfattning : During the period from 1984 to 1994 great changes occurred in the situation for drug addicts In Stockholm. The HIV-infection among intravenous drug addicts was detected in 1984 and a general HIV-screening started in 1985. LÄS MER
13. Genetic factors and the role of the NMDA receptor in pain modulation and the effect of opioids
Sammanfattning : Pain perception and the response to opioid analgesics are determined by a number of factors, among which genetic variability and the activation of the NMDA-receptor for glutamate play an important role. The effects of two clinically available NMDA-receptor antagonists, ketamine (KET) and dextromethorphan (DEX), were evaluated on an animal model of acute nociception, the hot plate test, and on human experimental acute ischemic pain. LÄS MER
14. Genetic differences in neuropathy and opioid responses in rats
Sammanfattning : The studies examined mechanisms and treatments of experimental neuropathic pain with particular emphasis on the differences between rat strains and sub-strains in basal nociceptive sensitivity, development of neuropathic behaviors and sensitivity to opioid analgesia. In order to study the mechanisms that mediate mechanical allodynia (touch-evoked pain) following ischemic nerve injury to the sciatic nerve in rats, the myelinated primary afferents have been examined in the injured and intact nerves. LÄS MER
15. Novel Microextraction Techniques for Bioanalysis of Neurotransmitters and Biomarkers in Biological Fluids
Sammanfattning : Sample preparation (sample pre-treatment) is the initial step and an essential part in bioanalysis procedure. The main role of sample preparation is to extract and transfer the analyte(s) of interest from a complex matrix to a purified media such as a pure solvent for analysis and quantification. LÄS MER
