Sökning: "methacholine responsiveness"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden methacholine responsiveness.

  1. 1. Optimizing and evaluation of a methacholine provocation test : with application in occupational research

    Författare :Britt-Marie Sundblad; Bengt-Eric Skoogh; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; Airway responsiveness; methacholine provocation; nitric oxide; eucapnic hyperventilation; organic dust; Fysiologi; Physiology; Fysiologi; Physiology; fysiologi;

    Sammanfattning : We have developed a methacholine provocation method, which detects bronchial responsiveness in more than 80% of healthy subjects. The method enables us to detect differences in bronchial responsiveness within the normal range. With this method FEV1 and Gaw had similar sensitivity in detecting small differences in bronchial responsiveness. LÄS MER

  3. 2. Airway responsiveness and exhaled nitric oxide : Studies in asthma and Sjögren's syndrome

    Författare :Dóra Lúðvíksdóttir; Uppsala universitet; []
    Nyckelord :Medical sciences; Airway hyperresponsiveness; nitric oxide; airway inflammation; Sjögren s syndrome; asthma; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : In this thesis, four different types of provocation agents: methacholine, adenosine, cold air and mannitol were used to study different aspects of the airway responsiveness profile in asthma and Sjögren's syndrome. Exhaled nitric oxide (NO) and markers of eosinophil activation, serum eosinophil peroxidase (S-EPO) and eosinophil cationic protein (S-ECP) were measured. LÄS MER

  4. 3. Airway effects of diesel exhaust in healthy and asthmatic subjects

    Författare :Charlotta Nordenhäll; Thomas Sandström; Ellinor Ädelroth; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; air pollution; diesel exhaust; airway responsiveness; airway inflammation; lung function; asthmatics; immunohistochemistry; bronchial epithelium;

    Sammanfattning : Several epidemiological studies have revealed an association between particulate matter (PM) pollution and various health effects. Importantly, there is evidence to suggest that individuals with pre-existing respiratory disease, such as asthma, are more sensitive to elevated ground levels of particulate matter as compared to healthy subjects. LÄS MER

  5. 4. The effect of beta2-adrenoceptor agonists and steroids on induced airway inflammation and bronchial responsiveness

    Författare :Karin Strandberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute exposure of healthy subjects in a swine barn induces an intense airway inflammation and increased bronchial responsiveness. Dust collected in swine houses is a potent stimulus for release of pro-inflammatory cytokines from cells in vitro. LÄS MER

  7. 5. Clinical studies of asthma phenotypes focusing on the role of the leukotrienes

    Författare :Per Gyllfors; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :>asthma; aspirin intolerance; leukotrienes; leukotriene D4 responsiveness; methacholine responsiveness; exhaled nitric oxide;

    Sammanfattning : Inflammation in the airways in connection to asthma is a complex phenomenon and the mechanisms underlying the associated clinical symptoms involve the interaction of many different kinds of cells and mediators, giving rise to different phenotypes. The aim of the present thesis was to investigate the molecular and cellular mechanisms that results in two of these phenotypes, i. LÄS MER