Sökning: "methacholine challenge"
Visar resultat 1 - 5 av 14 avhandlingar innehållade orden methacholine challenge.
1. Optimizing and evaluation of a methacholine provocation test : with application in occupational research
Sammanfattning : We have developed a methacholine provocation method, which detects bronchial responsiveness in more than 80% of healthy subjects. The method enables us to detect differences in bronchial responsiveness within the normal range. With this method FEV1 and Gaw had similar sensitivity in detecting small differences in bronchial responsiveness. LÄS MER
2. The asthmatic airway response – effects on physiology and biomarkers
Sammanfattning : Asthma is a common airway inflammatory disease, associated with a variable degree of airway obstruction. It is a heterogeneous condition with large variations in severity and clinical presentation. Moreover, disease activity can vary from time to time. Taken together, these factors make the diagnosis, monitoring and treatment of asthma challenging. LÄS MER
3. Effect of allergen specific immunotherapy on allergic inflammation in the upper and lower airways
Sammanfattning : Experimental allergen challenge is widely used in diagnostic practice and research in allergy, but its relationship to environmental exposures is not clarified. Both models of allergic diseases have been used in order to examine the effects of allergen specific immunotherapy (SIT). LÄS MER
4. Clinical studies of asthma phenotypes focusing on the role of the leukotrienes
Sammanfattning : Inflammation in the airways in connection to asthma is a complex phenomenon and the mechanisms underlying the associated clinical symptoms involve the interaction of many different kinds of cells and mediators, giving rise to different phenotypes. The aim of the present thesis was to investigate the molecular and cellular mechanisms that results in two of these phenotypes, i. LÄS MER
5. From sneeze to wheeze: Non-invasive studies on asthma and rhinitis
Sammanfattning : Asthma and allergic rhinitis are diseases that cause major disability and illness in all ethnic groups and ages. It is well established that allergic rhinitis and asthma are closely linked entities and more than 75 % of the patients with asthma reports concomitant rhinitis. LÄS MER