Sökning: "metastatic growth pattern"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden metastatic growth pattern.

  1. 1. Stromal collagens in colorectal cancer and in colorectal liver metastases : tumour biological implications and a source for novel tumour markers

    Författare :Hanna Nyström; Malin Sund; Peter Naredi; Per Sandström; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; colorectal liver metastases; tumour marker; stroma; type IV collagen; metastatic growth pattern; kirurgi; Surgery;

    Sammanfattning : Background: Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality. About 50 % of patients with CRC will develop subsequent liver metastases (CLM). The survival for untreated CLM is only a few months and liver resection provides the only chance for a lasting cure. LÄS MER

  3. 2. Metastatic Breast Cancer: Biomolecular Characterization and Targeted Therapy

    Författare :Siker Kimbung; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic breast cancer; biomarker conversion; liver metastasis-selective genes; prognosis; BRCA1; PARP1;

    Sammanfattning : Metastasis is a complex process that remains a major challenge in the clinical management of cancer, because most cancer-related deaths are attributed to disseminated disease rather than the primary tumor. Despite the significant advances in the prediction of prognosis, and therapeutic management of primary breast cancers, coupled with the substantial improvement in our understanding of the molecular determinants of metastasis, breast cancer relapse and death rates remain unacceptably high. LÄS MER

  4. 3. Mechanisms behind growth of castration-resistant prostate cancer bone metastases

    Författare :Emma Jernberg; Pernilla Wikström; Jack Schalken; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; castration-resistance; bone metastases; androgen receptor; intratumoral steroidogenesis; androgen receptor splice variants; androgen receptor amplification; patologi; Pathology;

    Sammanfattning : Background: The first-line treatment for patients with advanced prostate cancer (PC) is androgen deprivation therapy. This therapy is initially effective, but after some time tumors relapse, predominantly within the bone, and are then termed castration-resistant prostate cancer (CRPC). LÄS MER

  5. 4. Markers for clinical outcome and therapy response in soft tissue sarcomas

    Författare :Jan Åhlen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Soft-tissue sarcomas (STSs) constitute a heterogeneous group of rare but aggressive tumors that originate from mesenchymal cells in almost any part of the body. Gastrointestinal stromal tumor (GIST), located in the gastrointestinal tract, is the most common type of STS. LÄS MER

  7. 5. Adjuvant tamoxifen in breast cancer : clinical and preclinical studies on the prediction value of estrogen receptor

    Författare :Mahmoud Reza Khoshnoud; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Breast cancer (BC) exhibits great heterogeneity at histophatological, clinical and molecular levels. However, the different clinical outcomes in patients with seemingly similar breast cancer have led scientists to search for subgroups or for factors and characteristics related to the tumor or the patient that could anticipate clinical course (prognosis) of disease and/or response to given therapy (prediction). LÄS MER