Sökning: "metastatic cancer"

Visar resultat 1 - 5 av 315 avhandlingar innehållade orden metastatic cancer.

1. 1. Type IV collagen in breast and colorectal cancer : a potential biomarker of metastatic disease

   Författare :Moa Lindgren; Hanna Nyström; Ingrid Ljuslinder; Malin Sund; Kristian Pietras; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; colorectal liver metastases; breast cancer; breast cancer metastases; tumor marker; biomarker; stroma; type IV collagen;

   Sammanfattning : Background: Metastatic colorectal cancer (mCRC) and metastatic breast cancer (mBC) are two leading causes of cancer-related mortality worldwide. Early detection of metastatic disease is critical, and sensitive, easily accessed and cost-effective biomarkers that can diagnose mBC and mCRC at an early stage would have high clinical value. LÄS MER

3. 2. Utility of novel drug targets for treatment of metastatic cancer

   Författare :Tianyan Wang; Jenny Persson; Thomas Grundström; Maréne Landström; Margareta Wilhelm; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic cancer; castration-resistant prostate cancer; pancreatic ductal adenocarcinoma; target therapy; PIP5K1α; KRAS; molecularly imprinted polymers; Oncology; onkologi; molekylärbiologi; Molecular Biology; Medical Cell Biology; medicinsk cellbiologi;

   Sammanfattning : Metastasis is the leading cause of cancer death because of a lack of early diagnosis tools and efficient treatment drugs. The lipid kinase phosphatidylinositol 4-phosphate 5 kinase (PIP5K1α) has been shown to play a vital role in the PI3K/AKT and KRAS signaling pathways. LÄS MER

4. 3. Improved oncological treatment of anal cancer

   Författare :Otilia Leon; Tumörmikromiljö; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anal cancer; chemotherapy; Radiotherapy; Prognosis and survival; phase I II trial; Cetuximab; metastatic;

   Sammanfattning : Background: Squamous cell cancer of the anus (SCCA) is a rare malignancy, but the incidence is increasing. It isassociated with humman papilloma virus infection. The standard treatment is radiotherapy (RT) combined withchemotherapy, usually 5-fluorouracil (5FU)/Mitomycin C (MMC). LÄS MER

5. 4. Cancer Immunotherapy : A Preclinical Study of Urinary Bladder Cancer

   Författare :Christina Ninalga; Thomas Tötterman; Magnus Essand; Timothy Ratliff; Uppsala universitet; []
   Nyckelord :Medicine; immunotherapy; bladder carcinoma; cancer; CpG ODNs; Adenoviral vector; CD40L; TRANCE; Lymphotactin; IL2; IL15; Medicin;

   Sammanfattning : Bacillus Calmette Guérin (BCG), or attenuated Mycobacterium bovis, is the gold standard of immunotherapy in the clinic to treat superficial bladder cancer. However, setbacks remain due to a high recurrence rate, side effects, and BCG-refractory disease. LÄS MER

7. 5. Wnt-5a signaling in breast cancer metastasis

   Författare :Annette Säfholm; Malmö Experimentell patologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Patologi allmän ; patologisk anatomi; General pathology; cancer; onkologi; Cytologi; breast cancer; Wnt-5a; migration; pathological anatomy; metastasis; signal transduction; peptides; Cytology; cancerology; oncology;

   Sammanfattning : Breast cancer is the most common form of malignancy affecting women in the Western world. Today, anticancer treatment can control primary breast tumors, but treatment and prevention of metastatic disease still represents a major challenge in the management of breast cancer patients. LÄS MER