Sökning: "metal-catalysed transformation"
Hittade 5 avhandlingar innehållade orden metal-catalysed transformation.
1. Transition metal-catalysed enol formation from allylic alcohols : Isomerisation, C−C and C−F bond formations
Sammanfattning : This thesis describes the isomerisation of allylic alcohols into enols and enolates catalysed by transition metal complexes. The transformation has been used to prepare both unsubstituted and α-substituted carbonyl compounds. Significant attention has been given to the mechanistic aspects of the reactions. LÄS MER
2. Enzymes as catalysts in synthesis of enantiomerically pure building blocks : secondary alcohols bearing two vicinal stereocenters
Sammanfattning : Enzymes as tools in organic synthesis have provided enormous advantages. This thesis deals with the applications of enzymes in the kinetic resolutions of racemic compounds. The stereochemistry of chiral compounds and the kinetics of α/β hydrolase lipases are presented. LÄS MER
3. Transition metal-catalysed hydrogen transfer processes for C-C and C-N bond formation : Synthetic studies and mechanistic investigations
Sammanfattning : This thesis focusses on synthetic studies and mechanistic investigations into reactions involving hydrogen-transfer processes.In the first part, the development of an efficient method for the synthesis of β-hydroxy ketones (aldols) and β-amino ketones (Mannich products) from allylic alcohols and aldehydes is described. LÄS MER
4. C–H activation through late transition metal cyclometallation. Addressing selectivity and reactivity problems
Sammanfattning : The ligand-directed C—H activation relies on a coordinating donor atom being in proximity to the C—H bond activated. Cyclometallation of 2-(1-naphthyl)-pyridine – a substrate containing both γ- and δ-positions in proximity to the directing nitrogen atom – was studied. LÄS MER
5. New Reactivity in Diaryliodonium Salt Chemistry
Sammanfattning : Diaryliodonium salts (Ar2IX) have emerged as versatile multi-purpose reagents with desirable properties such as easy accessibility, low toxicity and applicability under mild and metal-free reaction conditions. Despite displaying broad utility in arylations of both carbon and heteroatom nucleophiles, the overall sustainability of these protocols is compromised by featuring poor atom economy due to the formation of stochiometric iodoarene byproducts. LÄS MER
