Sökning: "metal cofactor"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden metal cofactor.

  1. 1. To metal, or not to metal : Diverse mechanisms of O2-activation and radical storage in the ferritin superfamily

    Författare :Vivek Srinivas; Martin Högbom; Brian Hoffman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Metalloprotein; di-metal; Oxygen activation; Substrate oxidation; Ribonucleotide reductase; Radical; DOPA; ADE-DOT; X-Ray free-electron laser; soluble Methane monooxygenase; Biochemistry; biokemi;

    Sammanfattning : Proteins in the Ferritin-like superfamily are characterized by a four alpha-helical structural motif. These proteins are distributed across all three kingdoms of life and perform a wide range of functions. LÄS MER

  3. 2. Folding and Structure of Azurin - The Influence of a Metal

    Författare :Johan Leckner; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; azurin; metal cofactor; disulfide bond; protein folding; solution structure; protein stability; paramagnetic NMR;

    Sammanfattning : The structural role of the metal in the protein azurin from Pseudomonas aeruginosa has been a long standing question. Azurin belongs to the cupredoxin family and is a 128 residue beta-barrel protein of greek-key topology. LÄS MER

  4. 3. Assembly and Function of Nitric Oxide Reductase from Paracoccus denitrificans

    Författare :Maximilian Kahle; Pia Ädelroth; Hans-Georg Koch; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; non-heme iron; cofactor; heme-copper oxidase; AAA ; cNOR; chaperone; metal ion insertion; MoxR; nor accessory genes; FeB; liposomes; membrane mimetics; nanodiscs; reconstitution; enzymatic mechanism; NO reduction; O2 reduction; Biochemistry; biokemi;

    Sammanfattning : Bacterial denitrification is a part of the global nitrogen cycle and comprises the stepwise reduction of nitrate to molecular nitrogen, which is released to the atmosphere. Cytochrome c-dependent nitric oxide reductase (cNOR) from Paracoccus (P.) denitrificans catalyzes the reduction of nitric oxide to nitrous oxide and water. LÄS MER

  5. 4. Human copper ion transfer : from metal chaperone to target transporter domain

    Författare :Moritz Sebastian Niemiec; Pernilla Wittung-Stafshede; Nigel Robinson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; copper homeostasis; copper chaperone; Atox1; ATP7B; Wilson disease protein; metal transport; size exclusion chromatography; thermodynamics; isothermal calorimetry;

    Sammanfattning : Many processes in living systems occur through transient interactions among proteins. Those interactions are often weak and are driven by small changes in free energy. LÄS MER

  7. 5. Activation and inhibition of diiron and iron-manganese ribonucleotide reductases

    Författare :Ana Popović-Bijelić; Astrid Gräslund; Anders Hofer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; class Ic; C. trachomatis; cytotoxicity; KP772; lanthanum; manganese–iron cofactor; metal complex; oligopeptide inhibitor; ribonucleotide reductase; Triapine; tyrosyl radical; Biophysics; biofysik;

    Sammanfattning : Ribonucleotide reductase (RNR) catalyses the reduction of ribonucleotides to deoxyribonucleotides. In conventional class I RNRs the active site is located in the R1 subunit, and the R2 subunit contains a diiron cofactor and a stable tyrosyl radical essential for activity. LÄS MER