Sökning: "metabotropic receptor"

Visar resultat 1 - 5 av 27 avhandlingar innehållade orden metabotropic receptor.

  1. 1. Behavioural and biochemical pharmacology of adenosine/dopamine receptor/receptor interaction

    Författare :Roberto Rimondini-Giorgini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adenosine; A; receptors; A2A receptors; dopamine; D1 receptors; D2 receptors; mGluR receptors; striatum; immediately early genes; c-fos; junB; NGFI-A; microdialysis; receptor binding; in situ hybridisation;

    Sammanfattning : The neurotransmitter dopamine seems to be involved in neuropsychiatric diseases such as schizophrenia and Parkinson's disease. Direct blockade of dopamine receptors of the D2 subtype has been the hallmark of pharmacotherapy for schizophrenia since early 1950s. LÄS MER

  3. 2. Distribution and modulatory roles of neuropeptides and neurotransmitters in the Drosophila brain

    Författare :Lily Kahsai Tesfai; Åsa M. E. Winther; Ronald Strauss; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; central complex; locomotor behavior; co-transmitter; metabotropic receptor; metabolic stress; Neurobiology; Neurobiologi; zoologi; Zoology;

    Sammanfattning : The central complex is a prominent neuropil found in the middle of the insect brain. It is considered as a higher center for motor control and information processing. LÄS MER

  4. 3. Beyond AMPA and NMDA: Slow synaptic mGlu/TRPC currents : Implications for dendritic integration

    Författare :Marcus Petersson; Erik Fransén; Abdel El Manira; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; transient receptor potential; TRP; metabotropic glutamate receptor; mGlu1 5; dendritic integration; synaptic activation; temporal summation; low-frequency; entorhinal cortex; mathematical model; computational neuroscience; Computer science; Datavetenskap;

    Sammanfattning : In order to understand how the brain functions, under normal as well as pathological conditions, it is important to study the mechanisms underlying information integration. Depending on the nature of an input arriving at a synapse, different strategies may be used by the neuron to integrate and respond to the input. LÄS MER

  5. 4. Neuromodulation within a spinal locomotor network : role of metabotropic glutamate receptor subtypes

    Författare :Petronella Kettunen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :mGluR1; mGluR5; spinal cord; modulation; glutamate; NMDA; leak channel; locomotion; endocannabinoids; lamprey.;

    Sammanfattning : The metabotropic glutamate receptors, mGluRs, are G-protein coupled receptors. They consist of eight cloned subtypes, which are divided into three groups depending on the amino acid sequence similarity, pharmacology and their signal pathways. LÄS MER

  7. 5. Striatal pathways in dyskinesia and dystonia

    Författare :Laura Andreoli; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Striatum; Dystonia; L-DOPA-induced dyskinesia; DREADD; Mouse model; Dopamine; dopamine receptor;

    Sammanfattning : Purposeful and well-coordinated movements depend on the control exerted by dopamine (DA) on the basal ganglia (BG) network. Accordingly, dysfunctions or lesions of the dopaminergic system in the BG can result in an overall poverty and slowness of movement, cardinal features of Parkinson´s disease (PD), or in dyskinesias, exaggerated and involuntary movements resulting from L-DOPA pharmacotherapy. LÄS MER