Sökning: "metabotropic glutamate receptors"
Visar resultat 1 - 5 av 21 avhandlingar innehållade orden metabotropic glutamate receptors.
1. On the role of metabotropic glutamate receptors in motor control : analysis of synaptic, cellular and network properties
Sammanfattning : The organization of neurons into neuronal networks is a basic feature of the central nervous system. An understanding of the function of neuronal networks requires knowledge on both synaptic connectivity and cellular properties. LÄS MER
2. Mechanisms in Tendon Healing : Pain, Biomarkers and the Role of Mast Cells
Sammanfattning : Tendon injuries and tendinopathy are common disorders, but the underlying mechanisms are not well understood. The overall aim of this thesis was to better understand the mechanisms underlying tendon healing, pain, and inflammation. LÄS MER
3. Neuromodulation within a spinal locomotor network : role of metabotropic glutamate receptor subtypes
Sammanfattning : The metabotropic glutamate receptors, mGluRs, are G-protein coupled receptors. They consist of eight cloned subtypes, which are divided into three groups depending on the amino acid sequence similarity, pharmacology and their signal pathways. LÄS MER
4. Cell-penetrating peptides : Uptake mechanism and the role of receptors
Sammanfattning : Genes are the major regulators of biological processes in every living thing. Problems with gene regulation can cause serious problems for the organism; for example, most cancers have some kind of genetic component. Regulation of biological processes using oligonucleotides can potentially be a therapy for any ailment, not just cancer. LÄS MER
5. Structure-based Virtual Screening for Ligands of G Protein-coupled Receptors : Design of Allosteric and Dual-Target Modulators
Sammanfattning : G protein-coupled receptors (GPCRs) are integral membrane proteins responsible for signal transduction of extracellular stimuli into the cell. Because of their widespread distribution throughout the human body and important roles in physiological processes, GPCRs are prominent drug targets and approximately 34% of all approved drugs interact with members of this superfamily. LÄS MER