Sökning: "metabolic inhibition"

Visar resultat 6 - 10 av 208 avhandlingar innehållade orden metabolic inhibition.

  1. 6. Cytochrome P450 enzymes affected by artemisinin antimalarials-pharmacokinetic and pharmacogenetic aspects

    Författare :Sara Asimus; Göteborgs universitet; []
    Nyckelord :artemisinin; autoinduction; cytochrome P450; induction; inhibition; malaria; metabolism; pharmacogenetics; pharmacokinetics; probe;

    Sammanfattning : With more than 500 million cases and at least 1 million deaths each year, malaria is a major global health problem. The main problem with malaria control is the emerging drug resistance among parasites causing the infection. Consequently, there is an urgent need for new drugs. LÄS MER

  3. 7. Enzymatic Reduction of Ketones

    Författare :Magnus Carlquist; Teknisk mikrobiologi; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; inhibition; flavonoids; anthracyclines; human carbonyl reductase 1; kinetic resolution; Asymmetric bioreduction; bicyclic diketones; Saccharomyces cerevisiae; Escherichia coli; AKR; SDR;

    Sammanfattning : Methods have been studied for the production of chiral alcohols, which are of importance in organic synthesis of pharmaceuticals, agro-chemicals and fragrances, etc., through the enzymatic or microbial reduction of ketones. LÄS MER

  4. 8. Gill EROD Activity in Fish : A Biomarker for Waterborne Ah-receptor Agonists

    Författare :Alexandra Abrahamson; Ingvar Brandt; Björn Brunström; Janneche Utne Skaare; Uppsala universitet; []
    Nyckelord :Biology; biomarker; fish; gill; CYP1A; EROD; environmental monitoring; induction; inhibition; PAH; PCB; produced water; Biologi;

    Sammanfattning : Induction of the cytochrome P450(CYP)1A protein and the connected increase in 7-ethoxyresorufin O-deethylase (EROD) activity are common biomarkers in fish. Enhanced activity of this protein signals exposure to Ah-receptor agonists such as chlorinated dioxins, co-planar polychlorinated biphenyls (PCBs) and certain polycyclic aromatic hydrocarbons (PAHs). LÄS MER

  5. 9. Influence of metabolic disturbance on nervous function : clinical and experimental studies

    Författare :Lars Hyllienmark; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The present work consists of clinical and experimental studies and describes some effects of metabolic disturbance on nervous function. It is an electrophysiological examination of both single cells and patients exposed to metabolic insult or disease. LÄS MER

  7. 10. Interference with biological rhythm : a novel approach to metabolic disorders in women

    Författare :Roger Karlsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; GH; cholecystokinin; CCK; osteocalcin; angiotensinogen; diurnal variation; oral contraception; pregnancy; menopause;

    Sammanfattning : Women seem to be largely protected against certain ‘welfare disorders’ such as cardiovacular disease and osteoporosis, during their fertile years.The metabolic changes observed during women’s non-menstrual states, i.e. LÄS MER