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Visar resultat 1 - 5 av 27 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Adapt, Survive or Die - Metabolic Imbalances and the Enteric Nervous System

   Författare :Ulrikke Voss; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enteric nervous system; high fat diet; neuropathy; neuroplasticity; metabolic imbalance;

   Sammanfattning : Abstract: In this thesis the questions “do enteric neurons adapt to survive in conditions of obesity/type 2-diabetes (T2D) related metabolic imbalances? Or do they die?” are asked. Obese and T2D patients have high rates of gastrointestinal (GI) symptoms. LÄS MER

3. 2. Metabolic and Lifestyle related risk factors for pancreatic cancer

   Författare :Dorthe Johansen; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; trypsinogen; body mass index; alcohol consumption; smoking; Keywords: Pancreatic cancer; epidemiology; pancreatic secretory trypsin inhibitor; Helicobacter pylori; metabolic syndrome.;

   Sammanfattning : Background and aims: In spite of the fact that pancreatic cancer is a relatively infrequent disease, it ranks 8th in the worldwide ranking of cancer death due to the poor prognosis. The mortality rate is almost as high as the incidence with a M/I ratio of 98%, indicating an extremely dismal clinical course. LÄS MER

4. 3. Spices in the postprandial metabolic regulation of healthy humans : An integrated physiological and omics approach

   Författare :Yoghatama Cindya Zanzer; Avdelningen för livsmedel och läkemedel; []
   Nyckelord :Spices; Postprandial; Glycemia; Lipemia; Appetite regulation; Metabolic endotoxemia; Bile acids; Transcriptomics; Nutrigenomics;

   Sammanfattning : Metabolic syndrome (MetS) is a consequence of obesity and defined as cluster of at least three out of five criteria covering insulin resistance/glucose intolerance, abdominal obesity, hypertension, low HDL-c and elevated TG levels. Imbalance between energy intake and expenditure is known to alter normal physiological function in many aspects, and leads to obesity, which in the long run may turn into type 2 diabetes (T2D) and ultimately cardiovascular disease (CVD). LÄS MER

5. 4. Energy metabolic failure within the arterial wall in atherosclerosis

   Författare :Max Levin; Göteborgs universitet; []
   Nyckelord :atherosclerosis; hypoxia; hypoxia marker; bioluminescence imaging; ATP; glucose; lactate; energy metabolism;

   Sammanfattning : Atherosclerosis is a disease that affects large and medium sized arteries. The majority of deaths in a Western population can be directly attributed to complications of this disease. Although research efforts have been vast, the pathophysiological mechanisms underlying atherosclerosis are not fully understood. LÄS MER

7. 5. Muscle protein synthesis : effects of metabolic stress and feeding

   Författare :Inga Tjäder; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Surgical trauma and critical illness are pathophysiological conditions where the metabolic stress leads to an imbalance between protein synthesis and protein breakdown, resulting in a net loss of body proteins. A major part of the protein losses comes from skeletal muscle. Muscle depletion is associated with a high morbidity and mortality. LÄS MER