Sökning: "metabolic enzymes"

Visar resultat 1 - 5 av 245 avhandlingar innehållade orden metabolic enzymes.

  1. 1. Engineering enzymes towards biotherapeutic applications using ancestral sequence reconstruction

    Författare :Natalie Hendrikse; Per-Olof Syrén; Johan Rockberg; Erik Nordling; Reinhard Sterner; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; enzyme engineering; enzyme evolution; ancestral sequence reconstruction; therapeutic enzymes; terpene cyclases; ammonia-lyases; sulfatases; lysosomal enzymes; Kemi; Chemistry;

    Sammanfattning : Enzymes are versatile biocatalysts that fulfill essential functions in all forms of life and, therefore, play an important role in health and disease. One specific application of enzymes in life science is their use as biopharmaceuticals, which typically benefits from high catalytic activity and stability. LÄS MER

  3. 2. On metabolic networks and multi-omics integration

    Författare :Rasmus Ågren; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; succinate; genome-scale metabolic model; metabolic engineering; systems biology; penicillin; NASH; flux balance analysis; metabolism; cancer; reconstruction;

    Sammanfattning : Cellular metabolism is a highly complex chemical system, involving thousands of interacting metabolites and reactions. The traditional approach to understanding metabolism has been that of reductionism; by isolating and carefully measuring the involved components, the goal has been to understand the whole as the sum of its parts. LÄS MER

  4. 3. Metabolic Engineering of Synechocystis PCC 6803 for Butanol Production

    Författare :Rui Miao; Peter Lindblad; Pia Lindberg; Felix Ho; Shota Atsumi; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Synechocystis PCC 6803; biofuel; isobutanol; 1-butanol; metabolic engineering; protein engineering; Biokemi; Biochemistry;

    Sammanfattning : There is an urgent demand for renewable alternatives to fossil fuels since the extraction and utilization cause a series of environmental problems in the world. Thus, the utilization of solar energy has attracted much attention in the last decades since there is excess amount of light on Earth. LÄS MER

  5. 4. Metabolic engineering of Saccharomyces cerevisiae for polyhydroxybutyrate production

    Författare :Kanokarn Kocharin; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; S. cerevisiae; Acetyl-CoA; NADPH; Metabolic engineering; Polyhydroxybutyrate;

    Sammanfattning : Establishing industrial biotechnology for the production of chemical compounds from the biosynthetic pathway has received a significant boost with the implementation of metabolic engineering. At present, metabolic engineering in Saccharomyces cerevisiae gains significant advantages of integration of knowledge acquired through a long history of use and data acquisition from novel –omics technologies hence enabling the development of a tailor-made S. LÄS MER

  7. 5. Mitochondrial differentiation during the early development of the amphibian embryo

    Författare :Lennart Nelson; Barbara Cannon; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amphibia; Xenopus laevis; Ambystoma mexicanum; mitochondria; differentiation; enzymes; carriers; oxidation; development; Zoophysiology; zoofysiologi;

    Sammanfattning : Mitochondria from Xenopus laevis and Ambystoma mexica- num embryos between fertilization and the beginning of feeding were studied: the former with respect to metabolic behaviour, enzyme pattern and carrier activity, and the latter with respect to morphological parameters.The metabolic behaviour of mitochondria was studied by assessing the rates of oxygen uptake in presence of various substrates. LÄS MER