Sökning: "metabolic activation"

Visar resultat 16 - 20 av 293 avhandlingar innehållade orden metabolic activation.

  1. 16. Receptors for growth hormone and prolactin. Regulation and activation

    Författare :Gunnel Hellgren; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; GH receptor; Janus kinase; GH sensitivity; 5 -untranslated region; prolactin; prolactin receptor adipose tissue; liver; skeletal muscle; epidermal growth factor receptor; tyrosine kinase; kinase activity;

    Sammanfattning : Cytokine receptor activation is dependent on ligand-induced receptor dimerization or oligomerization and subsequent activation of several intracellular proteins. Activation of Janus kinases (Jaks) is probably the first intracellular event that occurs after receptor dimerization. LÄS MER

  3. 17. Energy flow and metabolic efficiency attributed to brown adipose tissue

    Författare :Gabriella von Essen; Jan Nedergaard; Susanne Klaus; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Brown adipose tissue; BAT; UCP1; diet-induced thermogenesis; DIT; obesity; high-fat diet; energy expenditure; fysiologi; Physiology;

    Sammanfattning : The large capacity of brown adipose tissue (BAT) to expend energy as heat makes it an interesting potential player in weight regulation and other metabolic conditions. This is of particular interest as it has been recognized that adult humans possess BAT. LÄS MER

  4. 18. Estrogen signaling in metabolic disease : a functional genomics approach

    Författare :Hui Gao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :estrogen receptor; insulin sensitivity; functional genomics; mouse liver; lipid metabolism;

    Sammanfattning : Estrogens have traditionally been associated with female reproduction. More and more evidence has also linked estrogens to maintenance of glucose homeostasis and normal heart function. LÄS MER

  5. 19. Mutational Analysis and Redesign of Alpha-class Glutathione Transferases for Enhanced Azathioprine Activity

    Författare :Olof Modén; Bengt Mannervik; Mikael Widersten; Kenneth Tew; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; allelic variants; azathioprine; bioactivation; chimeric mutagenesis; directed evolution; DNA shuffling; enzyme engineering; glutathione transferase; GST; lysate screening; molecular docking; multiple alignment; multivariate analysis; polymorphism; principal component analysis; prodrug; prodrug activation; protein engineering; protein redesign; reduced amino acid alphabet; saturation mutagenesis; semi-rational enzyme engineering; site-directed mutagenesis; structure-activity relationship; structure-based redesign; Biokemi; Biochemistry;

    Sammanfattning : Glutathione transferase (GST) A2-2 is the human enzyme most efficient in catalyzing azathioprine activation. Structure-function relationships were sought explaining the higher catalytic efficiency compared to other alpha class GSTs. LÄS MER

  7. 20. Novel aspects of metabolic regulation and inflammation in human adipocytes

    Författare :Annie Pettersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The significance of adipose tissue and obesity has been recognized in numerous pathologies. However, the mechanisms behind this connection are not yet completely understood. LÄS MER