Sökning: "mesolimbic"
Visar resultat 1 - 5 av 29 avhandlingar innehållade ordet mesolimbic.
1. Source localisation of epileptiform activity in epilepsy of temporal lobe origin
Sammanfattning : In patients with drug resistant partial epilepsy, who are under consideration for epilepsy surgery, interictal and ictal EEG recorded with extracranial electrodes plays an important role in the localisation of the seizure onset area. During the past years, methods have been developed, which can be used to estimate the location of the source of epileptiform activity in the brain from extracranial EEG data. LÄS MER
2. The gut-brain axis and alcohol-mediated behaviours: the amylin story
Sammanfattning : Alcohol use disorder (AUD) is a complex neuropsychiatric disorder with high rates of mortality and morbidity. The currently available pharmacotherapies show varied efficacy, leading to the investigation of new neurochemical targets for alcohol. LÄS MER
3. Nicotinic mechanisms in ethanol reinforcement. A neurochemical and behavioral study
Sammanfattning : Both smoking and alcohol consumption are known to cause severe health problems and there is an extensive co-abuse of tobacco and ethanol. The reinforcing properties of drugs of abuse may involve the brain mesolimbic dopamine system, that originates in the ventral tegmental area (VTA) and projects mainly to the nucleus accumbens. LÄS MER
4. Preclinical investigations of GlyT-1 inhibition as a new concept for treatment of alcohol dependence
Sammanfattning : Alcohol addiction and abuse is a main contributor to the global burden of disease and is a high public health priority. Alcohol addiction is a chronically relapsing neurobiological disorder affecting multiple neurotransmitter systems. LÄS MER
5. Neurochemical and behavioral studies on ethanol and brain opiod interactions in the brain
Sammanfattning : Substance dependence is a devastating disorder that produces enormous socio-economic costs, personal tragedies and health related problems. The brain mesolimbic dopamine pathway originating in the ventral tegmental area (VTA) with projections to limbic brain structures such as the nucleus accumbens has been implicated in the reinforcing effects of different drugs of abuse. LÄS MER