Sökning: "mesangial"

Visar resultat 11 - 15 av 26 avhandlingar innehållade ordet mesangial.

  1. 11. Renal effects of C-peptide in experimental type-1 diabetes mellitus

    Författare :Björn Samnegård; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Diabetic nephropathy; C-peptide; captopril; albuminuria; glomerular hyperfiltration; glomerular hypertrophy; glomerular mesangium expansion; type-IV collagen; RAGE; renal blood flow;

    Sammanfattning : The incidence and prevalence of diabetic nephropathy are increasing continuously, mainly due to the increase in type-2 diabetes. In contrast, the risk of diabetic nephropathy for the individual patient has decreased considerably in recent decades due to improved glycemic control, successful treatment of hypertension and hyperlipidemia and the use of renin angiotensin system inhibitors, which have protective effects beyond those on blood pressure. LÄS MER

  3. 12. Conditional targeting of the PDGF-B gene

    Författare :Maria Enge; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gene targeting; Cre loxP; PDGF; pericytes; diabetic retinopathy; brain injury; neurons;

    Sammanfattning : Platelet derived growth factors (PDGF) are known as mitogens for fibroblasts, smooth muscle cells (SMC) and glia cells in culture. Previous in vivo analyses have shown that PDGF-B is necessary for normal embryonic development and life after birth, but the relative importance of the various cellular sources of PDGF-B during development has not been clarified. LÄS MER

  4. 13. Antiapoptotic effect of ouabain in renal cells exposed to toxic glucose levels

    Författare :Liang Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes mellitus is a group of metabolic diseases that causes enormous social and economic burden. The kidney is the filtration organ that produces urine and is the primary target of diabetic complications, a condition called diabetic nephropathy (DN). LÄS MER

  5. 14. Mechanisms and treatment options of chronic graft dysfunction : Experimental and clinical studies

    Författare :Lilija Zezina; Uppsala universitet; []
    Nyckelord :Medical sciences; chronic graft dysfunction; kidney transplantation; aorta transplantation; lipid oxidation; LDL; TGF-beta; Smad2; angiotensin II receptor; treatment; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Chronic graft dysfunction (CGD) is an important post-transplant complication. CGD can be considered as an impaired repair process, which ultimately leads to the loss of graft function.To study non-immunological factors contributing to the development of CGD in kidney grafts we used in vitro and in vivo models, and clinical studies. LÄS MER

  7. 15. Role of new podocyte-associated proteins in the renal ultrafiltration barrier

    Författare :Angelina Schwarz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic kidney disease (CKD) is a major health problem and an economical burden affecting people worldwide. The main causes of CKD are diabetes and hypertension and patient numbers keep increasing. LÄS MER