Sökning: "memory CD8 T cells"
Visar resultat 1 - 5 av 72 avhandlingar innehållade orden memory CD8 T cells.
1. Approaches to analyses of cytotoxic cells. And studies of their role in H. pylori infection
Sammanfattning : Helicobacter pylori infection causes chronic gastritis that may progress to peptic ulcers or gastric adenocarcinoma and thereby cause major world-wide health problems. Previous studies have shown that CD4+ T cells and the production of the cytokine IFN- × are important components of the immune response to H. pylori in humans. LÄS MER
2. Regulation of T cell effector functions in the intestinal mucosa
Sammanfattning : T lymphocytes are a critical cellular component of the adaptive immune response. They are generated in the thymus from bone marrow derived progenitors, where they undergo commitment to the T cell lineage and differentiate and mature into naïve CD4+ and CD8+ T cells. LÄS MER
3. Peripheral immunity in patients with autoimmune endocrine diseases and the influence of physiological adaptions during pregnancy
Sammanfattning : Type 1 diabetes (T1D), Hashimoto’s thyroiditis (HT), Graves’ disease (GD), and autoimmune Addison’s disease (AD) appear to share immunogenetic mechanisms. This idea is not novel, as “autoimmune tautology” is an established concept. LÄS MER
4. CD8alpha/alpha+ T-cells and immune memory
Sammanfattning : A better understanding of T-cell memory formation is crucial for rationale vaccine design and the identification of correlates of immune protection. The CD8αα homodimer expressed on CD8+ T-cells is not anymore considered to represent a TCR co-receptor, it may rather represent a mechanism to modulate T-cell avidity and identify a subset of memory T-cells. LÄS MER
5. Immune maturation in early childhood and the influence of herpesvirus infections
Sammanfattning : The quality of immune responses develops from birth into adulthood and in the context of the host microbial environment. The aim of this work was to study immune maturation during childhood, and how this process can be affected by the common herpesviruses; Epstein-Barr virus (EBV) and cytomegalovirus (CMV). LÄS MER