Sökning: "membrane-trafficking"
Visar resultat 6 - 10 av 16 avhandlingar innehållade ordet membrane-trafficking.
6. The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking
Sammanfattning : The large protein family called G Protein-coupled receptors (GPCRs) has co-evolved with life throughout evolution; from single cell organisms all the way to complex beings such as us humans. The fact that GPCRs are involved in essentially every physiological event, and that ~50% of drugs on the current market are either directly or indirectly targeted towards the function of GPCRs, we can be certain of their considerable importance. LÄS MER
7. Membrane Stress and the Role of GYF Domain Proteins
Sammanfattning : Intracellular membrane trafficking is regulated by a large number of protein complexes and lipids. Blocking of trafficking disrupts normal membrane dynamics and causes membrane stress. LÄS MER
8. Cell signaling by Rho and Miro GTPases : Studies of Rho GTPases in Cytoskeletal Reorganizations and of Miro GTPases in Mitochondrial Dynamics
Sammanfattning : The Ras superfamily of GTPases embraces six major branches of proteins: the Ras, Rab, Ran, Arf, Rho and Miro subfamilies. The majority of GTPases function as binary switches that cycle between active GTP-bound and inactive GDP-bound states. This thesis will focus primarily on the biological functions of the Rho and Miro proteins. LÄS MER
9. Functional characterization of interactions between the flavivirus NS5 protein and PDZ proteins of the mammalian host
Sammanfattning : Flaviviruses are found all over the world and affect and infect millions of people every year. Flavivirus infection can lead to severe clinical outcomes resulting in neuronal damages e.g. Tick-borne encephalitis virus (TBEV), or severe hemorrhagic fevers e. LÄS MER
10. Plasma Membrane Proteomics and Functional Characterization & Expression Profiling of Plant Aquaporins
Sammanfattning : In order to identify integral and peripheral proteins associated with the plasma membrane (PM), highly purified Arabidopsis PMs were analyzed by mass spectrometry. In total, 238 putative PM proteins were identified, of which 114 were predicted to have transmembrane domains or to be PM-anchored. LÄS MER