Sökning: "membrane protein prediction"

Visar resultat 6 - 10 av 45 avhandlingar innehållade orden membrane protein prediction.

1. 6. Formalizing life : Towards an improved understanding of the sequence-structure relationship in alpha-helical transmembrane proteins

   Författare :Håkan Viklund; Arne Elofsson; Kimmen Sjölander; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; protein; topology; hidden Markov model; prediction; Bioinformatics; Bioinformatik; Biochemistry; biokemi;

   Sammanfattning : Genes coding for alpha-helical transmembrane proteins constitute roughly 25% of the total number of genes in a typical organism. As these proteins are vital parts of many biological processes, an improved understanding of them is important for achieving a better understanding of the mechanisms that constitute life. LÄS MER

3. 7. Theoretical studies of Membrane Proteins : Properties, Prediction Methods and Genome-wide analysis

   Författare :Erik Wallin; David Jones; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biology; Biochemistry; Biokemi;

   Sammanfattning : Membrane proteins are a large and important class of proteins. They are responsible for several of the key functions in a living cell, e.g. transport of nutrients and ions, cell-cell signaling, and cell-cell adhesion. LÄS MER

4. 8. What’s in? What’s out? And how did it get there? : Studies on topologies and insertion of membrane proteins

   Författare :Marie Österberg; Gunnar von Heijne; Peter Rehling; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; membrane protein; topology; yeast; mitochondria; TIM23; Biochemistry; Biokemi; Biochemistry; biokemi;

   Sammanfattning : Because of their hydrophobic and hydrophilic nature and the need for a lipid bilayer for retaining the native structure, membrane proteins are hard to study. Nevertheless, they are important, as many of our diseases are related to membrane proteins and around 60% of the different pharmaceutical drugs are directed against a membrane proteins [1]. LÄS MER

5. 9. Membrane protein topology : prediction, experimental mapping and genome-wide analysis

   Författare :Johan Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Membrane proteins constitute a large and important class of proteins. They are responsible for many crucial processes in living cells, and about 25% of all proteins encoded by a typical genome are predicted to be membrane proteins. Despite their importance, very few structures have been determined at atomic resolution. LÄS MER

7. 10. Drug Partitioning into Natural and Artificial Membranes : Data Applicable in Predictions of Drug Absorption

   Författare :Caroline Engvall; Birgitta Tomkinson; Katarina Edwards; Sven Engström; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Bilayer disk; Cholesterol; Drug partitioning; Drugs; Electrostatic effects; Immobilized liposome chromatography; Liposome; Membrane protein; Model membrane; Oligonucleotide-liposome complex; Phospholipid; Phospholipid bilayer; Proteoliposome; Surfactant; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : When drug molecules are passively absorbed through the cell membrane in the small intestine, the first key step is partitioning of the drug into the membrane. Partition data can therefore be used to predict drug absorption. LÄS MER