Sökning: "membrane protein prediction"

Visar resultat 21 - 25 av 45 avhandlingar innehållade orden membrane protein prediction.

1. 21. Analyses of protein evolution, function, and architecture

   Författare :Anna Henricson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Proteins can evolve over time in many different ways. An ancestral protein sequence inherited in different species will gradually undergo changes in primary sequence and sometimes in domain architecture. Some of these changes will affect its function, and evolutionary analyses can be used to predict function shift. LÄS MER

3. 22. Theoretical prediction of ionisation properties of proteins

   Författare :Assen Koumanov; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : This work emphasises on elaboration of improved theoretical and computational methods for determination of protonation/deprotonation equilibria in proteins. It also aims to contribute for a better understanding on atomic level of ionisation properties of proteins and their role in structure-functional relationship. LÄS MER

4. 23. Modeling of voltage-gated ion channels

   Författare :Pär Bjelkmar; Erik Lindahl; Toby W. Allen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Molecular modeling; Molecular dynamics; Voltage-gating; Ion channels; Protein structure prediction; Chemistry; Kemi; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : The recent determination of several crystal structures of voltage-gated ion channels has catalyzed computational efforts of studying these remarkable molecular machines that are able to conduct ions across biological membranes at extremely high rates without compromising the ion selectivity. Starting from the open crystal structures, we have studied the gating mechanism of these channels by molecular modeling techniques. LÄS MER

5. 24. A computational approach to curvature sensing in lipid bilayers

   Författare :Federico Elías-Wolff; Alexander Lyubartsev; Max Berkowitz; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; curvature sensing; membrane curvature; cardiolipin; amphipathic helix; symmetric multimers; lipid bilayer; molecular dynamics; Biophysics; biofysik;

   Sammanfattning : Local curvature is a key driving force for spatial organization of cellular membranes, via a phenomenon known as membrane curvature sensing, where the binding energy of membrane associated macromolecules depends on the local membrane shape. However, the microscopic mechanisms of curvature sensing are not well understood. LÄS MER

7. 25. Making Sense of Antisense

   Författare :Johan Reimegård; Gerhart Wagner; Hanah Margalit; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; sRNA; miRNA; RNA; target prediction; SOLiD siRNA; E.coli; D.discoideum; Biology; Biologi; Bioinformatics; Bioinformatik; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : RNA is a highly versatile molecule with functions that span from being a messenger in the transfer from DNA to protein, a catalytic molecule important for key processes in the cell to a regulator of gene expression. The post-genomic era and the use of new techniques to sequence RNAs have dramatically increased the number of regulatory RNAs during the last decade. LÄS MER