Sökning: "membrane protein insertion"

Visar resultat 1 - 5 av 69 avhandlingar innehållade orden membrane protein insertion.

  1. 1. Membrane protein topogenesis

    Författare :Karin Öjemalm; Gunnar von Heijne; Tracy Palmer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; biokemi;

    Sammanfattning : The membranes of cells are highly complex and heterogeneous structures that fulfill multiple vital tasks. They form thin barriers that seal out the environment, thus defining the cell’s boundaries. LÄS MER

  3. 2. Intra- and intermolecular interactions in proteins : Studies of marginally hydrophobic transmembrane alpha-helices and protein-protein interactions

    Författare :Linnea E Hedin; Arne Elofsson; Susana Cristobal; Ismael Mingarro; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane proteins; membrane insertion; marginally hydrophobic helix; hydrophobicity; protein-protein interactions; LacY; GltPh; Cell and molecular biology; Cell- och molekylärbiologi; Biochemistry; Biokemi; Biochemistry; biokemi;

    Sammanfattning : Most of the processes in a living cell are carried out by proteins. Depending on the needs of the cell, different proteins will interact and form the molecular machines demanded for the moment. LÄS MER

  4. 3. Into the Membrane and Beyond : Improving Membrane Protein Over-Expression in Escherichia coli

    Författare :Mirjam Klepsch; Jan-Willem de Gier; Reinhard Grisshammer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; membrane protein over-expression; proteomics; T7 RNA polymerase; peptide transport; strain engineering; Biochemistry; Biokemi; Biophysical chemistry; Biofysikalisk kemi; biokemi; Biochemistry;

    Sammanfattning : Membrane proteins fulfil a wide variety of essential functions in the cell and many are (potential) drug targets. Since their natural abundance is usually very low, most membrane proteins have to be over-expressed for functional and structural studies. LÄS MER

  5. 4. Protein targeting, translocation and insertion in Escherichia coli : Proteomic analysis of substrate-pathway relationships

    Författare :Louise Baars; Jan-Willem de Gier; Jan-Maarten van Dijl; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein biogenesis; targeting; translocation; insertion; SecB; SecE; E. coli; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Approximately 10% of the open reading frames in the genome of the Gram-negative bacterium E. coli encodes secretory proteins, and 20% encodes integral inner membrane proteins (IMPs). LÄS MER

  7. 5. Sequence-based predictions of membrane-protein topology, homology and insertion

    Författare :Andreas Bernsel; Gunnar von Heijne; Volkhard Helms; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; membrane protein; topology prediction; hidden markov model; homology detection; Sec translocon; Bioinformatics; Bioinformatik; Biochemistry; biokemi;

    Sammanfattning : Membrane proteins comprise around 20-30% of a typical proteome and play crucial roles in a wide variety of biochemical pathways. Apart from their general biological significance, membrane proteins are of particular interest to the pharmaceutical industry, being targets for more than half of all available drugs. LÄS MER