Sökning: "membrane lipids analysis"
Visar resultat 1 - 5 av 42 avhandlingar innehållade orden membrane lipids analysis.
1. Exploring the Interplay of Lipids and Membrane Proteins
Sammanfattning : The interplay between lipids and membrane proteins is known to affect membrane protein topology and thus have significant effect (control) on their functions. In this PhD thesis, the influence of lipids on the membrane protein function was studied using three different membrane protein models. LÄS MER
2. Probing and elucidating the dynamics of virus-membrane interaction via plasma membrane mimics
Sammanfattning : Virus infection is initiated by the attachment of a virion to a susceptible cell’s plasma membrane, in a highly dynamic and well-orchestrated process that encompasses various steps and engages numerous viral and cellular factors. These dynamic steps may include initial non-specific binding to ubiquitous cell-membrane ligands, diffusion across the membrane to a suitable entry site and virus engagement with various receptors and co-receptors on the cell surface. LÄS MER
3. Label free analysis and spatial distribution of molecular lipids in brain tissue and cells using mass spectrometry imaging
Sammanfattning : Lipids are important inherent components in brain and cell membranes, which play significant biological roles in cell function. Identification and localization of specific biomolecules such as peptides and lipids within cellular membranes is currently a major challenge in metabolomics and biological studies. LÄS MER
4. Development of Enhanced Analytical Methodology for Lipid Analysis from Sampling to Detection : A Targeted Lipidomics Approach
Sammanfattning : This thesis covers a wide range of analytical method development for lipid analysis in complex biological samples; from sample preparation using pressurized fluid extraction (PFE) and separation with reversed phase capillary liquid chromatography (RP-LC) to detection by electrospray ionization mass spectrometry (ESI/MS) and tandem MS.The requirements for fast, reliable and selective extraction methods with minimal usage of solvents have accelerated the development of new extraction techniques. LÄS MER
5. Biophysical studies of membrane associated peptides
Sammanfattning : A large part of the processes in living organisms involves proteins acting in a biological membrane. Biophysical studies on isolated model systems can give important understandings of the complicated biological mechanisms in the membrane. In this thesis peptide membrane interaction mechanisms are studied in several different systems. LÄS MER