Sökning: "membrane channels"

Visar resultat 16 - 20 av 199 avhandlingar innehållade orden membrane channels.

  1. 16. Targeting the voltage-gated calcium channels as treatment for type 2 diabetes

    Författare :Pawel Buda; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autophagy; apoptosis; calcium channels; Type 2 Diabetes;

    Sammanfattning : L-type voltage-gated Ca2+ channels are expressed in the plasma membrane of muscles, neurons and endocrine cells where they serve as conductors of signals regulating cellular responses to changes in environment. Malfunctions of channels, as well as deregulations of their activity underlie numerous disorders and diseases commonly called channelopathies. LÄS MER

  3. 17. Integration and topology of membrane proteins

    Författare :Carolina Boekel; Gunnar von Heijne; IngMarie Nilsson; Stephen High; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; insertion; Sec61; translocation; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Membrane proteins comprise around 20-30% of most proteomes. They play important roles in most biochemical pathways. All receptors and ion channels are membrane proteins, which make them attractive targets for drug design. Membrane proteins insert and fold co-translationally into the endoplasmic reticular membrane of eukaryotic cells. LÄS MER

  4. 18. The involvement of calcium and membrane fusion events in neutrophil secretion and respiratory burst

    Författare :Daniel Granfeldt; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; calcium; regulated secretion; membrane fusion; SOC; arachidonic acid; intracellular fusion; oxygen free radicals; phagocytosis;

    Sammanfattning : Neutrophil granulocytes play an important role in host defence during the early stages of microbial infection. The neutrophils have to leave the blood stream and migrate out into the tissue where they are able to phagocytose and kill microbes as well as dispose of cell debris from damaged tissues. LÄS MER

  5. 19. Chloride Channels and Brown Fat Cells

    Författare :Victor Sabanov; Jan Nedergaard; Bernd Nilius; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chloride channel; BAPTA; EGTA; Ca; Animal physiology; Zoofysiologi;

    Sammanfattning : Chloride ion channels are macromolecular pores providing for passage of chloride ions (and certain other inorganic and organic anions) through the cell membrane, down their electrochemical gradients. Chloride channels are differentially expressed in various cells, to best suit specific cellular activities. LÄS MER

  7. 20. Voltage-Sensor Domains of Ion Channels : Physiology, Regulation, and Role in Disease

    Författare :Michelle Nilsson; Antonios Pantazis; Fredrik Elinder; Henry M. Colecraft; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Brain function depends on the ability of neurons to sense and respond to electricity, which is mediated by small modules in the neuronal membrane called voltage-sensor domains (VSDs). Disruption of VSD function can cause neurological disease such as epilepsy. LÄS MER