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Visar resultat 1 - 5 av 120 avhandlingar som matchar ovanstående sökkriterier.
1. Assessment of Novel Molecular Prognostic Markers in Chronic Lymphocytic Leukemia
Sammanfattning : The clinical course of chronic lymphocytic leukemia (CLL) is highly heterogeneous, which has prompted the search for biomarkers that can predict prognosis in this disease. The IGHV gene mutation status and certain genomic aberrations have been identified as reliable prognostic markers of clinical outcome for this disorder. LÄS MER
2. Evolution of protein and non-coding RNA genes studied with comparative genomics
Sammanfattning : The identification of protein and non-coding RNA (ncRNA) genes is one important step in the analysis of a genome. This thesis focuses on the identification and analysis of proteins and ncRNAs homologues by exploiting a variety of computational methods in order to reach conclusions as to their structure, function, evolution and regulation. LÄS MER
3. Superantigens in group A streptococcus : gene diversity and humoral immune response
Sammanfattning : Group A streptococcus (GAS) is a strictly human pathogen that causes infections ranging from asymptomatic carriage to the highly lethal streptococcal toxic shock syndrome (STSS). GAS are classified according to the sequence of the variable 5’ end of the emm-gene that encodes the surface associated M-protein. LÄS MER
4. High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities
Sammanfattning : High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. LÄS MER
5. Characterizing the pancreatic "isletome" : 3D optical imaging to study diabetes
Sammanfattning : The pancreas is a specialised multipurpose organ, that can be separated into two major compartments: endocrine and exocrine. The exocrine part makes up the majority of the organ volume and functions to secrete digestive enzymes into the small intestine. LÄS MER