Sökning: "medical biochemistry"

Visar resultat 6 - 10 av 455 avhandlingar innehållade orden medical biochemistry.

1. 6. Matrix degrading proteases in the ovary : expression and function

   Författare :Patrik Wahlberg; Tor Ny; Ilpo Huhtaniemi; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; ovary; ovulation; corpus luteum; plasminogen; PA; MMP; rat; mouse; Biokemi; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : Extracellular matrix degrading proteases from the plasminogen (plg) activator (PA) and the matrix metalloproteinase (MMP) systems have been implicated as important mediators of ovulation and corpus luteum (CL) formation and regression. The aim of this thesis was to investigate the expression and regulation of PAs and MMPs in the ovary and to examine their functional roles for CL formation and function. LÄS MER

3. 7. Studies of in vivo prostate amyloidosis and autoimmune responses towards amyloid structures in neurodegeneration

   Författare :Kiran Yanamandra; Ludmilla Morozova-Roche; Dina Raveh; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; amyloidosis; immune reactivity; S100A8 A9; insulin; α-synuclein; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : By using multidisciplinary analysis of CA inclusions in prostate glands of patients diagnosed with prostate cancer, we have revealed that their major components are the amyloid forms of S100A8 and S100A9 proteins associated with numerous inflammatory conditions and types of cancer. We have demonstrated that material closely resembling CA can be produced from S100A8/A9 in vitro and shows the characters of amyloids. LÄS MER

4. 8. Thermodynamical and structural properties of proteins and their role in food allergy

   Författare :Louise Rundqvist; Göran Larsson; Göran Karlsson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protein folding; NMR; Food allergy; allergen; protein interactions; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : Proteins are important building blocks of all living organisms. They are composed of a defined sequence of different amino acids, and fold into a specific three-dimensional, ordered structure. The three-dimensional structure largely determines the function of the protein, but protein function always requires motion. LÄS MER

5. 9. Studies on the transmembrane signaling of β1 integrins

   Författare :Annika Armulik; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Integrin β1; signaling; transmembrane domain; CAS; focal adhesion kinase; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

   Sammanfattning : Integrins are heterodimeric cell surface receptors, composed of an α and a β subunit, mainly binding for extracellular matrix proteins. lntegrin subunit β1 can combine with at least 12 a subunits and thus form the biggest subfamily within the integrin family. LÄS MER

7. 10. Functional studies in yeast of cyclin C and the RNA polymerase II Mediator complex

   Författare :Darius Balciunas; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Cyclin C; RNA polymerase II; Mediator; glucose repression; RAS cAMP pathway; Saccharomyces cerevisiae; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

   Sammanfattning : Cyclin C belongs to a group of cyclins that are not cell cycle-regulated. It was first cloned from Drosophila and rat, but its role was not understood until the yeast cyclin C homologue Srb 11 was identified in several genetic screens for transcriptional repressors and subsequently was shown to be associated with the RNA polymerase II Mediator complex. LÄS MER