Sökning: "medfödda skador"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden medfödda skador.

1. 1. Hematopoiesis: Functional Insights by Cell Fate Conversion

   Författare :Martin Wahlestedt; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Blood cell formation, or hematopoiesis, is maintained by rare hematopoietic stem cells (HSCs) residing in the bone marrow (BM). HSCs may self-renew (the process whereby HSCs replicate to produce new HSCs) to preserve their own numbers, as well as initiate a highly coordinated hierarchical differentiation process that results in the production of mature effector blood cells. LÄS MER

3. 2. Doppler evaluation of coronary blood flow and coronary flow reserve - Clinical and experimental studies

   Författare :Gylfi Oskarsson; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatrics; Pediatri; Cardiovascular system; Kardiovaskulära systemet; fetal asphyxia; transposition of the great arteries; dilated cardiomyopathy; aortic stenosis; child; neonate; adenosine; coronary flow reserve; Doppler; coronary flow;

   Sammanfattning : Heart diseases in children cause different combinations of myocardial hypertrophy, increased intra-ventricular pressures, volume overload and decreased oxygen saturation. This may affect basal coronary flow and the ability of the heart to maximally increase coronary flow. LÄS MER

4. 3. Novel findings on cellular trafficking and targeting for granule storage of neutrophil elastase, a multifunctional effector molecule of innate immunity

   Författare :Linda Källquist; Avdelningen för hematologi och transfusionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic cell; CD63; neutrophil elastase; targeting; trafficking; intracellular sorting; neutrophil; azurophil granule;

   Sammanfattning : Neutrophil elastase (NE) has important roles in innate immunity, killing pathogens and controlling the immune response; but how NE is targeted to developing granules is not understood. Therefore, the aim of this thesis was to investigate the sorting of NE. LÄS MER

5. 4. Interactions between extracellular matrix proteins and the complement system - In the perspective of cartilage degradation in inflammatory joint diseases

   Författare :Camilla Melin Fürst; Malmö Proteinkemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Complement system; rheumatoid arthritis; osteoarthritis; extracellular matrix; cartilage degradation; mass spectrometry;

   Sammanfattning : Abstract: The joint diseases osteoarthritis and rheumatoid arthritis are characterized by destructive inflammatory processes that result in pathological changes of the joint tissues, including proteolytic degradation of cartilage and release of extracellular matrix proteins or fragments to the synovial fluid. The complement system, which is a part of the innate immune system, plays a central role in promoting the joint inflammation in these diseases. LÄS MER

7. 5. On visual impairment in Swedish children

   Författare :Jonas Blohmé; Lund Oftalmologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ophtalmology; Sweden; sociology; mortality; outcome; epidemiology; registration; childhood blindness; Visual impairment; children; Oftalmologi;

   Sammanfattning : Knowledge of the epidemiology of visual impairment in children forms one of the cornerstones in paediatric ophthalmology. To gain an overview of the situation in Sweden an epidemiological study was performed. Totally 2373 visually impaired children were found, giving an age-specific prevalence of 10,9/10 000. Childhood blindness (i. LÄS MER