Sökning: "med2"

Hittade 3 avhandlingar innehållade ordet med2.

  1. 1. Studies of Functional Interactions within Yeast Mediator and a Proposed Novel Mechanism for Regulation of Gene Expression

    Författare :Magnus Hallberg; Stefan Björklund; Karl Ekwall; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Mediator; Transcriptional regulation; Srb10; Cdk8; Med2; Srb7; Med21; RNA pol II; Biokemi; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : The yeast Mediator complex is required for transcriptional regulation both in vivo and in vitro and the identification of similar complexes from metazoans indicates that its function is conserved through evolution. Mediator subunit composition and structure is well characterized both by biochemical, genetic and biophysical methods. LÄS MER

  3. 2. Functional studies in yeast of cyclin C and the RNA polymerase II Mediator complex

    Författare :Darius Balciunas; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Cyclin C; RNA polymerase II; Mediator; glucose repression; RAS cAMP pathway; Saccharomyces cerevisiae; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Cyclin C belongs to a group of cyclins that are not cell cycle-regulated. It was first cloned from Drosophila and rat, but its role was not understood until the yeast cyclin C homologue Srb 11 was identified in several genetic screens for transcriptional repressors and subsequently was shown to be associated with the RNA polymerase II Mediator complex. LÄS MER

  4. 3. Studies of the chromatin form of yeast Mediator and the function of its tail module

    Författare :Miriam Nilsson; Stefan Björklund; Claes Gustafsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mediator complex; Transcriptional regulation; yeast; tail module; transcription; medicinsk biokemi; Medical Biochemistry; molekylärbiologi; Molecular Biology;

    Sammanfattning : Mediator is a large, multifunctional complex that is conserved in eukaryotes. It was first discovered in Saccharomyces cerevisiaeas required for transcriptional activators to function in a reconstituted in vitro system. Mediator is also important for stimulation of basal, unregulated transcription, and transcriptional repression. LÄS MER