Sökning: "mechanistic empirical"

Visar resultat 6 - 10 av 35 avhandlingar innehållade orden mechanistic empirical.

  1. 6. Predictive Modeling of Lake Eutrophication

    Författare :Jan Mikael Malmaeus; Lars Håkanson; Kurt Pettersson; Jürg Bloesch; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Earth sciences; mass balance model; dynamic model; mechanistic model; phosphorus; LEEDS; suspended particulate matter; settling velocity; sedimentation; accumulation sediments; burial; diffusion; climate scenario; Erken; Balaton; Kinneret; Batorino; Miastro; Naroch; Galten; Ekoln; Geovetenskap; Earth sciences; Geovetenskap;

    Sammanfattning : This thesis presents predictive models for important variables concerning eutrophication effects in lakes. The keystone is a dynamic phosphorus model based on ordinary differential equations. LÄS MER

  3. 7. Modeling and Optimization of Reversed-Phase Chromatography : Effects of Modulators and Temperature

    Författare :Karolina Arkell; Avdelningen för kemiteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Reversed-phase chromatography; Hydrophobic interaction chromatography; Mechanistic modeling; INSULIN; KCl; Ethanol; Temperature; Multi-objective optimization; Constraint; Solubility;

    Sammanfattning : Many widespread diseases, such as diabetes, various types of cancer, and aggressive versions of influenza, are treated or prevented with biopharmaceuticals. Biopharmaceuticals are drugs that are based on proteins, peptides, antibodies, attenuated viruses (vaccines), and other biomolecules that are synthesized predominately in bacteria, yeast, and mammalian cells. LÄS MER

  4. 8. Towards an integrated ecology through mechanistic modelling of ecosystem structure and functioning

    Författare :Thomas Hickler; Institutionen för naturgeografi och ekosystemvetenskap; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pedology; cartography; climatology; Fysisk geografi; geomorfologi; marklära; kartografi; klimatologi; geomorphology; Physical geography; integrated ecology; plant hydraulic architecture; climate change; CO2 fertilisation effect; biogeography; biogeochemistry; vegetation dynamics; ecosystem modelling;

    Sammanfattning : Plant physiology, population dynamics and the structure and functioning of ecosystems are closely interrelated. However, these processes are often investigated independently within different subdisciplines of ecology. LÄS MER

  5. 9. Semi-mechanistic models of glucose homeostasis and disease progression in type 2 diabetes

    Författare :Steve Choy; Maria Kjellsson; Mats Karlsson; Willem de Winter; Andrea Mari; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; pharmacometrics; glucose homeostasis; insulin; type 2 diabetes; obesity; weight; visceral adipose tissue; HbA1c; non-linear mixed effects; modelling; disease progression; ZDSD rats; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by consistently high blood glucose, resulting from a combination of insulin resistance and reduced capacity of β-cells to secret insulin. While the exact causes of T2DM is yet unknown, obesity is known to be a major risk factor as well as co-morbidity for T2DM. LÄS MER

  7. 10. Computational Modeling of the Mechanisms and Selectivity of Organophosphate Hydrolases

    Författare :Miha Purg; Shina C. Lynn Kamerlin; Iñaki Tuñón; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Organophosphate Hydrolase; Computational enzymology; MPH; DFPase; PON1; Empirical Valence Bond; EVB;

    Sammanfattning : Computational modeling is becoming an increasingly integral part of (bio)chemistry, providing a powerful complementary view into the dynamics, binding, and reactivity of biochemical systems. In particular, molecular simulations based on multiscale models are now regularly employed in studies of enzymatic reactions, offering invaluable mechanistic insight through the lens of molecular energy landscapes. LÄS MER