Sökning: "mechanism-based"
Visar resultat 1 - 5 av 55 avhandlingar innehållade ordet mechanism-based.
1. Mechanism-Based Pharmacokinetic and Pharmacodynamic Modelling of Paclitaxel
Sammanfattning : Paclitaxel (Taxol®) is now widely used against breast, ovarian and non-small-cell lung cancer. Anticancer agents generally have narrow therapeutic indices, often with myelosuppression (mainly neutropenia) as dose-limiting side effect. LÄS MER
2. Mechanism-Based Modeling of the Glucose-Insulin Regulation during Clinical Provocation Experiments
Sammanfattning : Type 2 diabetes is a complex chronic metabolic disorder characterized by hyperglycemia associated with a relative deficiency of insulin secretion and a reduced response of target tissues to insulin. Considerable efforts have been put into the development of models describing the glucose-insulin system. LÄS MER
3. Mechanism-based flow stress model for Ti-6Al-4V : applicable for simulation of additive manufacturing and machining
Sammanfattning : Ti-6Al-4V has remarkable properties such as high specific mechanical properties (viz. stiffness, strength, toughness, fatigue resistance), corrosion resistance, biocompatibility etc. These properties make it attractive for applications in aerospace, chemical industry, energy production, surgical implants, etc. LÄS MER
4. Safety and Efficacy Modelling in Anti-Diabetic Drug Development
Sammanfattning : A central aim in drug development is to ensure that the new drug is efficacious and safe in the intended patient population. Mathematical models describing the pharmacokinetic-pharmacodynamic (PK-PD) properties of a drug are valuable to increase the knowledge about drug effects and disease and can be used to inform decisions. LÄS MER
5. Simulation of additive manufacturing using a mechanism based plasticity model
Sammanfattning : This thesis presents finite element (FE) simulations of additive manufacturing (AM) and physically based material modeling of alloy 625 and alloy 718. In recent years, there has been an increasing interest in AM and there has been a dramatic increase in publications in the field. LÄS MER