Sökning: "mechanism of glucocorticoid action"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden mechanism of glucocorticoid action.

1. 1. Mechanism of conditional repression of human osteocalcin gene activity by glucocorticoids

   Författare :Thomas Meyer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :glucocorticoid receptor; osteocalcin; gene regulation; TATA box element;

   Sammanfattning : Bone is one of the major target sites of steroid hormone action. Steroid hormones like cortisol, vitamin D and estradiol are responsible for principle events associated with bone formation and resorption. LÄS MER

3. 2. Functional analysis of ligand recognition by the glucocorticoid receptor

   Författare :Ulrika Lind; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :glucocorticoid receptor; steroid-binding; site-directed mutagenesis; protein-ligand interaction; mechanism of glucocorticoid action;

   Sammanfattning : The glucocorticoid receptor (GR) is a ligand-inducible transcription factor that belongs to the superfamily of nuclear hormone receptors. It contains three structural and functional domains. LÄS MER

4. 3. New Methods to Screen for Cancer Drugs and to Evaluate their Mechanism of Action

   Författare :Linda Rickardson; Rolf Larsson; Peter Nygren; Henrik Lövborg; Kjell Grankvist; Uppsala universitet; []
   Nyckelord :Pharmacology; Cancer drugs; Screening; Gene expression; Farmakologi;

   Sammanfattning : Cancer is a common disease and due to problems with resistance against cancer drugs and the limited benefit from chemotherapy in many diagnoses, there is a need to develop new cancer drugs. In this thesis new methods to screen for cancer drugs and to evaluate their mechanism of action are discussed. LÄS MER

5. 4. Studies on the therapeutic modulation of inflammation in the synovial membrane of rheumatoid arthritis

   Författare :Petra Neregård; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the synovial membrane that can lead to joint deformity and physical disability. Despite recent progress in the therapeutic field of RA, the exact molecular mechanisms responsible for chronic joint inflammation are not yet completely understood. LÄS MER

7. 5. Modulation of nuclear receptor function by interacting proteins

   Författare :Waffa Osman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Nuclear receptors are a family of transcription factors involved in many biological processes. They represent key potentials as therapeutic targets for several clinical conditions such as diabetes, obesity, cardiovascular disease and cancer, because their activity is modulated by small molecules. LÄS MER