Sökning: "mechanism of action"

Visar resultat 21 - 25 av 598 avhandlingar innehållade orden mechanism of action.

  1. 21. Viperin vs. tick-borne encephalitis virus : mechanism of a potent antiviral protein

    Författare :Kirstin Vonderstein; Anna Överby Wernstedt; Magnus Evander; Sonja Best; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus; TBEV; type-I interferon; IFN; Interferon-stimulated gene; ISG; viperin; GBF1; CIAO1; antiviral protein; genome replication; particle release; capsid;

    Sammanfattning : Tick-borne encephalitis virus (TBEV) is a very important virus medically, causing mild or severe encephalitis often with long-lasting sequelae. Treatment of tick-borne encephalitis is limited to supportive care, and antiviral drugs are much needed.The type-I interferon (IFN) system is the first line of host defense against many viruses. LÄS MER

  3. 22. Studies on the antiproliferative action of interferon : effects on proteins synthesized in the G1 and S phase of the cell cycle in 2 anchorage-dependent cell lines

    Författare :Dan Lundblad; Erik Lundgren; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Interferon; Glioma; Antiproliferative effect; DNA polymerase; Thymidine kinase; 2 -5 oligo A; Protein synthesis; Two-dimensional electrophorensis; Mouse fibroblasts; C-myc; KI-67 antigen;

    Sammanfattning : Interferons (IFNs) are a class of structurally related proteins first discovered to be produced by virus-infected cells. By now, several other inducing agents have been described. LÄS MER

  4. 23. Effects of loading mechanisms and texture on ore breakage – A multidimensional study

    Författare :Parisa Semsari Parapari; Magnus Evertsson; Luleå tekniska universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Breakage mechanism; Loading mechanism; Ore texture; Liberation; Comminution; Mineralteknik; Mineral Processing;

    Sammanfattning :  In comminution machines, the product properties (particle size distribution, mineral liberation characteristics) and process consumables (energy for size reduction, wear) are affected by various parameters. On the one hand, understanding and optimizing these parameters can provide an energy efficient process and a specified product. LÄS MER

  5. 24. Studies of molecular mechanisms of action of TNF antagonists in rheumatoid arthritis

    Författare :Anca Irinel Catrina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Rheumatoid arthritis; TNF antagonists; cytokines; macrophages; matrix metalloproteinases; osteoprotegerin; RANKL; apoptosis;

    Sammanfattning : Rheumatoid arthritis (RA) is a common chronic inflammatory disease characterized by progressive bone destruction that leads to joint deformity and physical disability. Even though several therapeutic drugs are available, none have emerged as an ideal RA treatment that delays joint destruction and halts disease progression. LÄS MER

  7. 25. Molecular Mechanisms of Action of Histidine-rich Glycoprotein in Angiogenesis Inhibition

    Författare :Chunsik Lee; Lena Claesson-Welsh; Jan Palmblad; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; anti-angiogenesis; angiogenesis inhibitor; endothelial cell; histidine-rich glycoprotein; focal adhesion; tumor-associated macrophages; VEGF; MMP; Cell- och molekylärbiologi;

    Sammanfattning : Angiogenesis, de novo synthesis of blood vessels from the pre-existing vasculature, is required both during embryonic development and in pathophysiological conditions. In particular, tumor growth needs new capillary vessels in order to both deliver oxygen and nutrients and to remove toxin and metabolites. LÄS MER