Sökning: "maximal tolerable dose"

Hittade 3 avhandlingar innehållade orden maximal tolerable dose.

1. 1. RADIOIMMUNOTHERAPY & EXTRACORPOREAL ADSORPTION Preclinical Studies of the Pharmacokinetics & Biotinylation of Radioimmunoconjugates in Immunocompetent Rats

   Författare :Zhongmin Wang; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; oncology; cancerology; Cytologi; Cytology; extracorporeal adsorption; tri-functional chelator; maximal tolerable dose; biotin; intraperitoneal administration; biodistribution; pharmacokinetics; biotinylation; radiolabeling; rat; monoclonal antibody; radionuclide;

   Sammanfattning : Extracorporeal adsorption (ECAT) is a novel strategy to reduce activity in whole body (WB), blood and radiosensitive organs by removing the excess of radiolabeled and biotinylated monoclonal antibody (MAb) from blood so that tumor/normal tissue ratio (T/N) could be improved. By increasing T/N, higher amounts of radiolabeled MAb might be administered, making it possible to treat disseminated carcinomas. LÄS MER

3. 2. High-Dose Radioimmunotherapy and Extracorporeal Depletion in A Syngeneic Rat Tumor Model

   Författare :Linda Mårtensson; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : ABSTRACT Radioimmunotherapy (RIT) consists of using monoclonal antibodies (mAbs) recognizing tumor-selective antigens, as carriers of cytotoxic radionuclides to tumor tissue. RIT has been effective in lymphoma but less successful in solid tumors. LÄS MER

4. 3. Ultraviolet radiation cataract development and ascorbate supplementation

   Författare :Vino C Jr Mody; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Background: Cataract is the major cause of blindness in the world, and long-term solar ultraviolet radiation (UVR) is a major risk factor. The pathogenesis of UVRinduced cataract is studied in various animal models and cell systems. LÄS MER