Sökning: "mattias belting"

Hittade 4 avhandlingar innehållade orden mattias belting.

  1. 1. On the binding of growth-promoting polyamines to proteoglycans: Implications for growth-regulation and polycation-mediated gene transfer

    Författare :Mattias Belting; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cationic lipid.; gene transfer; gene therapy; cell growth; polyamine transport; spermine; polyamine; growth-inhibition; heparan sulphate; dermatan sulphate; Proteoglycan; glycosaminoglycan; cytogenetics; Genetik; cytogenetik;

    Sammanfattning : Initial investigations were directed at studying the interaction between polyamines and various glycosaminoglycans (GAGs). The polyamine spermine displayed binding to dermatan sulphate (DS) and heparan sulphate (HS) with similar (Kd, 3.9 x 10-4 M) and higher (Kd, 0.37 x 10-6 M) affinity, respectively, than to DNA. LÄS MER

  2. 2. New preclinical strategies for characterization and development of anticancer drugs

    Författare :Henning Karlsson; Peter Nygren; Rolf Larsson; Mattias Belting; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; spheroids; green fluorescent protein; VLX50; VLX60; VLX600; nitazoxanide; radiation; radiosensitizer; Oncology; Onkologi;

    Sammanfattning : Increased understanding of the molecular mechanisms underlying cancer development has shifted drug discovery towards target driven drug development the last decades, but the development of effective cancer drugs has been hampered by the lack of predictive preclinical models. 3-D cultures, considered to more accurately reflect solid tumors in vivo, have been proposed as one way to increase the predictability of clinical efficacy in cancer drug discovery and development. LÄS MER

  3. 3. Biomarkers In Brain Tumors With Focus On Glioblastoma

    Författare :Malgorzata Lysiak; Peter Söderkvist; Annika Malmström; Olle Stål; Mattias Belting; Linköpings universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; MGMT; Biomarker; Sex differences; Androgen receptor; Loss of chromosome Y;

    Sammanfattning : The primary brain tumors, gliomas, are not very common but they are deadly. Each year in Sweden around 500 patients will be diagnosed with a glioma and unfortunately most of them will have the most aggressive type, glioblastoma (GBM). Median survival, even if treated, is poor (14-17 months). LÄS MER

  4. 4. Examining the role of metabolism in Myc-driven tumorigenesis

    Författare :Tacha Zi Plym Forshell; Jonas Nilsson; Mattias Belting; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; cancer; Myc; metabolism; polyamines; spermidine synthase; glycolysis; lactate dehydrogenase; serine metabolism; Phgdh; folate metabolism; Shmt; Pim kinase; Pim-3 Kinase; Molecular biology; Molekylärbiologi;

    Sammanfattning : Myc transcriptionally regulates genes involved in processes such as cell proliferation, metabolism, differentiation, and angiogenesis.  MYC expression is deregulated in many types of human cancer; therefore discovering the mechanisms behind MYCs role in tumorigenesis is essential. LÄS MER