Sökning: "matrix metalloproteases"

Visar resultat 6 - 10 av 11 avhandlingar innehållade orden matrix metalloproteases.

  1. 6. Molecular and clinical studies of cartilage and bone macromolecules in arthritis

    Författare :Bengt Månsson; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skeleton; Prognosis; Tissue damage; Bone markers; Cartilage markers; Rheumatoid arthritis; Psoriatic arthritis; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi;

    Sammanfattning : The pathogenesis of inflammatory arthritides include synovial inflammation and joint tissue destruction. Tissue destruction has traditionally been regarded a consequence of inflammation, but recent observations indicate that the processes are not always closely linked and may proceed uncoupled. LÄS MER

  3. 7. Regulation of cellular plasticity and extracellular vesicle secretion in breast cancer

    Författare :Chrysoula Tsirigoti; Aristidis Moustakas; Carl-Henrik Heldin; Pierre Savagner; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cellular plasticity; extracellular vesicles; breast cancer; EMT; Molekylär medicin; Molecular Medicine; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Epithelial-to-mesenchymal transition (EMT) is a dynamic process controlling the transition of cells between epithelial and mesenchymal states in various physiological or pathological conditions. In cancer, EMT promotes cell dissemination and metastatic colonization, enriches tumors with stem cell populations and confers resistance to anticancer therapy. LÄS MER

  4. 8. Implications of Heparan Sulfate and Heparanase in Inflammatory Diseases

    Författare :Andreas Digre; Jin-Ping Li; Lena Kjellén; Liliana Schaefer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparanase; Heparan sulfate; Inflammation; Inflammatory diseases; Autoimmune diseases; Amyloidosis; Reumathoid arthritis; SAA; APP; A beta; Neuroinflammation; Medical Science; Medicinsk vetenskap; Medical Biochemistry; Medicinsk biokemi; Immunologi; Immunology; Neurology; Neurologi;

    Sammanfattning : Heparan sulfate (HS), an unbranched sulfated carbohydrate chain, and the HS-degrading enzyme heparanase play important roles in physiological and pathological processes during all stages of life, from early embryogenesis to ageing. Accumulated information shows that HS and heparanase are involved in inflammatory processes and associated diseases, e. LÄS MER

  5. 9. Microfluidic Methods for Protein Microarrays

    Författare :Michael Hartmann; Johan Roeraade; Mike Taussig; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Protein microarray technology has an enormous potential for in vitro diagnostics (IVD)1. Miniaturized and parallelized immunoassays are powerful tools to measure dozens of parameters from minute amounts of sample, whilst only requiring small amounts of reagent. LÄS MER

  7. 10. TGFβ Signal Transduction in Endothelial Cells

    Författare :Gudrun Valdimarsdóttir; Peter ten Dijke; Carl-Henrik Heldin; Christer Betsholtz; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi;

    Sammanfattning : Transforming growth factor β (TGFβ) is a multifunctional cytokine that is involved in many biological effects, such as proliferation, migration, differentiation and cell survival. TGFβ regulates cellular responses by binding to a heteromeric complex of type I and type II serine/threonine kinase receptors. LÄS MER