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Visar resultat 1 - 5 av 11 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Matrix metalloproteases and cell motility in malignant mesothelioma

    Författare :Zhiwen Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Matrix; metalloproteases MMPs ; cell motility; growth factors; malignant mesothelioma; invasion;

    Sammanfattning : Invasion and metastasis of malignant tumor cells requires destruction of and migration through extracellular matrix (ECM) such as basement membrane and interstitial stroma. The ECM-degrading proteases produced by tumor cells and stromal cells and cell motility play a crucial role in this process. LÄS MER

  3. 2. The effects of flaxseed and tamoxifen on the inflammatory microenvironment in normal breast tissue and in breast cancer

    Författare :Gabriel Lindahl; Charlotta Dabrosin; Signe Borquist; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; inflammation; chemoprevention; tamoxifen; phytoestrogens; flaxseed; enterolactone; interleukins; osteopontin; chemokines; matrix metalloproteases; microdialysis;

    Sammanfattning : Breast cancer is the most common cancer among women worldwide today. Nearly 9000 women are diagnosed with breast cancer in Sweden yearly and despite advantages in diagnostics and treatments approximately 1400 women still die from their disease every year. LÄS MER

  4. 3. Matrix degrading proteases in the ovary : expression and function

    Författare :Patrik Wahlberg; Tor Ny; Ilpo Huhtaniemi; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; ovary; ovulation; corpus luteum; plasminogen; PA; MMP; rat; mouse; Biokemi; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Extracellular matrix degrading proteases from the plasminogen (plg) activator (PA) and the matrix metalloproteinase (MMP) systems have been implicated as important mediators of ovulation and corpus luteum (CL) formation and regression. The aim of this thesis was to investigate the expression and regulation of PAs and MMPs in the ovary and to examine their functional roles for CL formation and function. LÄS MER

  5. 4. Studies of cell migration and matrix protease production in human lung cancer cell lines

    Författare :Cecilia G Bredin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Lung cancer; extracellular matrix; growth factors; matrix metalloproteases; integrins; migration; invasion;

    Sammanfattning : Metastatic spread in cancer is a complex multistep process involving continuous, sequential interactions between tumour cells and their respective microenvironment. Invasiveness per se has not been studied in this thesis, only some of its major components, such as cell migration and matrix protease production. LÄS MER

  7. 5. The importance of astroglial cells in ischemia, regeneration and angiogenesis

    Författare :Andrea Lundkvist; Göteborgs universitet; []
    Nyckelord :astrocytes; Müller cells; retina; intermediate filaments; GFAP; vimentin; angiogenesis; VEGF-A; guidance; matrix-metalloprotease;

    Sammanfattning : Astrocytes in the CNS communicate with both neurons and blood vessels. In many CNS pathologies, astrocytes respond by becoming reactive. Whether their performance at this stage is beneficial or detrimental for CNS function is unclear. LÄS MER