Sökning: "mast cell-deficient rat Ws Ws"

Hittade 1 avhandling innehållade orden mast cell-deficient rat Ws Ws.

  1. 1. Role of mast cell-derived mediators for leukocyte/endothelium-interactions and microvascular mechanisms in inflammation and in anaphylaxis

    Författare :Yancai Guo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Anaphylaxis; histamine; intravital microscopy; leukocyte; mast cell-deficient rat Ws Ws ; microdialysis;

    Sammanfattning : The overall objective of this thesis was to study the roles of mast cell-derived mediators for leukocyte/endothelium interactions and microvascular mechanisms in inflammation and in anaphylaxis, using mast cell-deficient Ws/Ws rats and their wild-type +/+ littermates. The efflux of endogenous histamine and edema formation evoked by subplantar injection of compound 48/80 in rat hindpaws was dose-dependent in +/+ rats, and was essentially lacking in Ws/Ws rats. LÄS MER